College of Medicine: Recent submissions

Now showing items 601-620 of 1514

    • Covid-19 in pediatric patients: A focus on CHD patients 

      Zareef, Rana O.; Younis, Nour K.; Bitar, Fadi; Eid, Ali H.; Arabi, Mariam ( Frontiers Media S.A. , 2020 , Article)
      Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2 virus. As of the 30th of September 2020, around 34,000,000 cases have been reported globally. Pediatrics with underlying congenital heart disease ...

    • The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: Impact beyond reduced clotting 

      Alaaeddine, Rana A.; AlZaim, Ibrahim; Hammoud, Safaa H.; Arakji, Aya; Eid, Ali H.; ... more authors ( Portland Press Ltd , 2021 , Article Review)
      Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made ...

    • Differential response of oxidative and glycolytic skeletal muscle fibers to mesterolone 

      Asfour, Hasan A.; Shaqoura, Emad I.; Said, Raed S.; Mustafa, Ayman G.; Emerald, Bright Starling; ... more authors ( Nature Research , 2021 , Article)
      Oxidative and glycolytic muscle fibers differ in their ultrastructure, metabolism, and responses to physiological stimuli and pathological insults. We examined whether these fibers respond differentially to exogenous ...

    • Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes 

      Rabbani, Naila ( Portland Press Ltd , 2022 , Article)
      The study of the glyoxalase system by Thornalley and co-workers in clinical diabetes mellitus and correlation with diabetic complications revealed increased exposure of patients with diabetes to the reactive, dicarbonyl ...

    • β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat 

      Pearson, James T.; Thambyah, Hamish P.; Waddingham, Mark T.; Inagaki, Tadakatsu; Sukumaran, Vijayakumar; ... more authors ( Portland Press Ltd , 2021 , Article)
      A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) ...

    • Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort 

      Drake, Isabel; Hindy, George; Almgren, Peter; Engström, Gunnar; Nilsson, Jan; ... more authors ( Nature Research , 2021 , Article)
      Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ...

    • Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis 

      Halabi, Reem; Dakroub, Fatima; Haider, Mohammad Z.; Patel, Stuti; Amhaz, Nayef A.; ... more authors ( preprints , 2023 , Preprint)
      Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ...

    • Biological applications of imiquimod analogues: An update (Review) 

      Obeid, Joelle; Shaito, Abdullah; Hajj, Hiba El; Deleuze-Masquefa, Carine; Bonnet, Pierre Antoine; ... more authors ( Spandidos Publications , 2023 , Article Review)
      The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...

    • Biochemical and cellular basis of oxidative stress: Implications for disease onset 

      Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; ... more authors ( Wiley , 2023 , Article Review)
      Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...

    • Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 

      Rafael, Lozano; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M; ... more authors ( Elsevier , 2020 , Article)
      Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority ...

    • Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 

      Haidong, Wang; Abbas, Kaja M; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; ... more authors ( Elsevier , 2020 , Article)
      Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, ...

    • Five insights from the Global Burden of Disease Study 2019 

      Christopher J L, Murray; Abbafati, Cristiana; Abbas, Kaja M; Abbasi, Mohammad; Abbasi-Kangevari, Mohsen; ... more authors ( Elsevier , 2020 , Article Review)
      The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system ...

    • The power of genetic diversity in genome-wide association studies of lipids 

      Graham, Sarah E.; Clarke, Shoa L.; Wu, Kuan Han H.; Kanoni, Stavroula; Zajac, Greg J.M.; ... more authors ( Nature Research , 2021 , Article)
      Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ...

    • A longitudinal analysis of the effect of maternal region-of-birth on transitions in children's bodyweight status from early childhood to late adolescence in Australia: A population-based cohort study 

      Hartono, Susan; Cochrane, Tom; Niyonsenga, Theo; Kinfu, Yohannes ( Elsevier , 2021 , Article)
      Although 49% of Australian residents have at least one overseas-born parent, little is known about children's longitudinal bodyweight transitions among the migrant population. This study examines the net associations between ...

    • Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs 

      Toth, Krisztian; Nagi, Karim; Slosky, Lauren M.; Rochelle, Lauren; Ray, Caroline; ... more authors ( American Chemical Society , 2019 , Article)
      G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement ...

    • Pravastatin plus L-arginine prevents adverse pregnancy outcomes in women with uteroplacental vascular dysfunction 

      Jurisic, Aleksandar; Jurisic, Zaklina; Lefkou, Eleftheria; Girardi, Guillermina ( Elsevier , 2021 , Article)
      Background: Uteroplacental vascular dysfunction, characterized by diminished uterine artery (UtA) blood flow in the second trimester is a clinically useful predictor of the further development of preeclampsia, fetal growth ...

    • Author Correction: Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer 

      Mastrogamvraki, Natalia; Zaravinos, Apostolos ( NLM (Medline) , 2020 , Article)
      In the original version of this Article, the wrong images were supplied for Figures 7 and 10. This has now been corrected in both the HTML and PDF versions of the Article.

    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; ... more authors ( Nature Research , 2022 , Article)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...

    • KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals 

      Thillaiappan, Nagendra Babu; Smith, Holly A.; Atakpa-Adaji, Peace; Taylor, Colin W. ( Nature Research , 2021 , Article)
      Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile ...

    • COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response 

      Souchelnytskyi, Serhiy; Nera, Andriy; Souchelnytskyi, Nazariy ( Nature Research , 2021 , Article)
      Clinical reports show that the management of cancer patients infected with SARS-CoV-2 requires modifications. Understanding of cancer-relevant mechanisms engaged by the virus is essential for the evidence-based management ...