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    Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review

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    Date
    2022-12-01
    Author
    Shah, Naheed Sidiq
    Thotathil, Vandana
    Zaidi, Shabi Abbas
    Sheikh, Hanan
    Mohamed, Maimoona
    Qureshi, Ahmadyar
    Sadasivuni, Kishor Kumar
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    Abstract
    Over the last decades, molecularly imprinted polymers (MIPs) have emerged as selective synthetic receptors that have a selective binding site for specific analytes/target molecules. MIPs are synthetic analogues to the natural biological antigen–antibody system. Owing to the advantages they exhibit, such as high stability, simple synthetic procedure, and cost-effectiveness, MIPs have been widely used as receptors/sensors for the detection and monitoring of a variety of analytes. Moreover, integrating electrochemical sensors with MIPs offers a promising approach and demonstrates greater potential over traditional MIPs. In this review, we have compiled the methods and techniques for the production of MIP-based electrochemical sensors along with the applications of reported MIP sensors for a variety of analytes. A comprehensive in-depth analysis of recent trends reported on picomolar (pM/10−12 M)) and beyond picomolar concentration LOD (≥pM) achieved using MIPs sensors is reported. Finally, we discuss the challenges faced and put forward future perspectives along with our conclusion.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144500886&origin=inward
    DOI/handle
    http://dx.doi.org/10.3390/bios12121107
    http://hdl.handle.net/10576/42843
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