Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review
Author | Shah, Naheed Sidiq |
Author | Thotathil, Vandana |
Author | Zaidi, Shabi Abbas |
Author | Sheikh, Hanan |
Author | Mohamed, Maimoona |
Author | Qureshi, Ahmadyar |
Author | Sadasivuni, Kishor Kumar |
Available date | 2023-05-17T08:32:07Z |
Publication Date | 2022-12-01 |
Publication Name | Biosensors |
Identifier | http://dx.doi.org/10.3390/bios12121107 |
Citation | Shah, N. S., Thotathil, V., Zaidi, S. A., Sheikh, H., Mohamed, M., Qureshi, A., & Sadasivuni, K. K. (2022). Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review. Biosensors, 12(12), 1107. |
Abstract | Over the last decades, molecularly imprinted polymers (MIPs) have emerged as selective synthetic receptors that have a selective binding site for specific analytes/target molecules. MIPs are synthetic analogues to the natural biological antigen–antibody system. Owing to the advantages they exhibit, such as high stability, simple synthetic procedure, and cost-effectiveness, MIPs have been widely used as receptors/sensors for the detection and monitoring of a variety of analytes. Moreover, integrating electrochemical sensors with MIPs offers a promising approach and demonstrates greater potential over traditional MIPs. In this review, we have compiled the methods and techniques for the production of MIP-based electrochemical sensors along with the applications of reported MIP sensors for a variety of analytes. A comprehensive in-depth analysis of recent trends reported on picomolar (pM/10−12 M)) and beyond picomolar concentration LOD (≥pM) achieved using MIPs sensors is reported. Finally, we discuss the challenges faced and put forward future perspectives along with our conclusion. |
Sponsor | This work was supported by the UREP grant # UREP28-063-1-008 from the Qatar National Research Fund (QNRF). |
Language | en |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Subject | electrochemical sensors limit of detection molecular imprinted polymer ultrasensitive |
Type | Article |
Issue Number | 12 |
Volume Number | 12 |
ESSN | 2079-6374 |
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