Browsing Biomedical Research Center Research by Author "Vranic, Semir"
Now showing items 1-20 of 23
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Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
Allouch, Soumaya; Gupta, Ishita; Malik, Shaza; Al Farsi, Halema F; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Co-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.
Al-Thawadi, Hamda; Ghabreau, Lina; Aboulkassim, Tahar; Yasmeen, Amber; Vranic, Semir; Batist, Gerald; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2018 , Article)Epstein-Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression ... -
Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
Gupta, Ishita; Ghabreau, Lina; Al-Thawadi, Hamda; Yasmeen, Amber; Vranic, Semir; Al Moustafa, Ala-Eddin; Malki, Mohammed I... more authors ... less authors ( Frontiers Media , 2020 , Article)High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the ... -
Co-presence of human papillomaviruses and Epstein-Barr virus is linked with advanced tumor stage: a tissue microarray study in head and neck cancer patients.
Al-Thawadi, Hamda; Gupta, Ishita; Jabeen, Ayesha; Skenderi, Faruk; Aboulkassim, Tahar; Yasmeen, Amber; Malki, Mohammed I; Batist, Gerald; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2020 , Article)Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this fact, we ... -
Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.
Padmanabhan, Regina; Kheraldine, Hadeel Shafeeq; Meskin, Nader; Vranic, Semir; Al Moustafa, Ala-Eddin ( Springer , 2020 , Article)Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2) and triple-negative breast cancers. Therapies ... -
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
Ashour, Anas; Alhussain, Hashim; Rashid, Umar Bin; Abughazzah, Labiba; Gupta, Ishita; Malki, Ahmed; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2020 , Article)E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
Mahmoud, Nouf N.; Zakaria, Zain Zaki; Kheraldine, Hadeel; Gupta, Ishita; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala Eddin Al... more authors ... less authors ( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Fascin in Gynecological Cancers: An Update of the Literature
Gupta, Ishita; Vranic, Semir; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin ( MDPI , 2021 , Article)Fascin is an actin-binding protein that is encoded by the gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different ... -
Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
Sareyeldin, Rasha M.; Gupta, Ishita; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema F.; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ... -
High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions
Allouch, Soumaya; Malki, Ahmed; Allouch, Asma; Gupta, Ishita; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Cervical cancer is the fourth most common malignancy in women worldwide and a leading cause of cancer-related mortality in developing countries. Important etiological factors in this cancer are high-risk human papillomaviruses ... -
High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.
Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; AlAhmad, Yaman M; Al Moustafa, Ala-Eddin; Vranic, Semir... more authors ... less authors ( MDPI , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
High-risk human papillomaviruses and epstein–barr virus in colorectal cancer and their association with clinicopathological status
Gupta, Ishita; Farsi, Halema Al; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; Alahmad, Yaman M.; Moustafa, Ala Eddin Al; Vranic, Semir... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
Gupta, Ishita; Jabeen, Ayesha; Vranic, Semir; Al Moustafa, Ala-Eddin; Al-Thawadi, Hamda ( Frontiers Media , 2021 , Article)Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ... -
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ... -
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
Vranic, Semir; Cyprian, Farhan Sachal; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ... -
SARS-CoV-2 Infection and Smoking: What is the association? A brief review
Ishita, Gupta; Sohail, Muhammad Umar; Elzawawi, Khaled E.; Amarah, Ahmed H.; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala-Eddin Al... more authors ... less authors ( Elsevier , 2021 , Article)Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ... -
Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.
Al-Qahdi, Shaikha S; Alzohari, Nada; Alsaid, Abrar Y; Ashour, Anas A; Aboulkassim, Tahar; Vranic, Semir; Al Moustafa, Ala-Eddin; Khalil, Ashraf A... more authors ... less authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the ... -
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
Kheraldine, Hadeel; Gupta, Ishita; Cyprian, Farhan; Vranic, Semir; Al Moustafa, Ala-Eddin ( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ...