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    SARS-CoV-2 Infection and Smoking: What is the association? A brief review

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    1-s2.0-S2001037021000957-main.pdf (845.7Kb)
    Date
    2021-03-23
    Author
    Ishita, Gupta
    Sohail, Muhammad Umar
    Elzawawi, Khaled E.
    Amarah, Ahmed H.
    Vranic, Semir
    Al-Asmakh, Maha
    Moustafa, Ala-Eddin Al
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    Abstract
    Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression.
    URI
    https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5
    DOI/handle
    http://dx.doi.org/10.1016/j.csbj.2021.03.023
    http://hdl.handle.net/10576/18031
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    • Biomedical Research Center Research [‎808‎ items ]
    • Biomedical Sciences [‎833‎ items ]
    • COVID-19 Research [‎849‎ items ]
    • Medicine Research [‎1819‎ items ]

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