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Now showing items 401-409 of 409
Characterization of the Efficacy of a Split Swine Influenza A Virus Nasal Vaccine Formulated with a Nanoparticle/STING Agonist Combination Adjuvant in Conventional Pigs
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Swine influenza A viruses (SwIAVs) are pathogens of both veterinary and medical significance. Intranasal (IN) vaccination has the potential to reduce flu infection. We investigated the efficacy of split SwIAV H1N2 antigens ...
Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in ...
The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity
(
Elsevier
, 2023 , Article)
BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse ...
The Role of Apolipoproteins in the Commonest Cancers: A Review
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the ...
Prevalence and genetic diversity of Blastocystis sp. among autochthonous and immigrant patients in Italy
(
Elsevier
, 2023 , Article)
The prevalence of Blastocystis sp., its genetic diversity and the distribution of circulating subtypes (STs) were molecularly investigated in a cohort of autochthonous and immigrant patients with gastrointestinal symptoms ...
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals
(
MDPI
, 2020 , Article)
Abstract: To support the deployment of serology assays for population screening during the
COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...
The prevalence of HEV among non-A-C hepatitis in Qatar and efciency of serological markers for the diagnosis of hepatitis E
(
BMC
, 2021 , Article)
Background: The rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers
who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acute ...
Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations
(
Frontiers Media SA
, 2023 , Article)
Amid the ongoing monkeypox outbreak, there is an urgent need for the rapid development of effective therapeutic interventions capable of countering the immune evasion mechanisms employed by the monkeypox virus (MPXV). The ...
Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system
(
Frontiers Media SA
, 2023 , Article)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surfaced on 31 December, 2019, and was identified as the causative agent of the global COVID-19 pandemic, leading to a pneumonia-like disease. One of its accessory ...