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المؤلفObeid, Joelle
المؤلفShaito, Abdullah
المؤلفHajj, Hiba El
المؤلفDeleuze-Masquefa, Carine
المؤلفBonnet, Pierre Antoine
المؤلفEl-Sabban, Marwan
المؤلفSaliba, Jessica
تاريخ الإتاحة2023-08-29T04:45:27Z
تاريخ النشر2023-06-01
اسم المنشورWorld Academy of Sciences Journal
المعرّفhttp://dx.doi.org/10.3892/wasj.2023.197
الاقتباسObeid J, Shaito A, El Hajj H, Deleuze‑masquefa C, Bonnet P, El‑Sabban M and Saliba J: Biological applications of imiquimod analogues: An update (Review). World Acad Sci J 5: 20, 2023
الرقم المعياري الدولي للكتاب26322900
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164812194&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46856
الملخصThe last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of clinical trials, with only a handful being translated from the bench to bedside. One such example is imiquimod, an immune response modi‑ fier belonging to the imidazoquinoline family. Imiquimod was first approved by the US Food and Drug Administration for the topical treatment of anal and genital warts and actinic keratosis, and later exhibited a potent antitumor activity. This promising activity inspired the development of several imid‑ azoquinoxaline analogues and derivatives. The present review provides a comprehensive overview of the scientific literature on the chemical synthesis of imiquimod and several of its analogues, namely EAPB0203, EAPB0503 and EABP02303. The present review also discusses their preclinical proper‑ ties and mechanisms of action in the context of cancer and parasitic infections, highlighting the worthiness of translating these activities into therapeutic drugs.
اللغةen
الناشرSpandidos Publications
الموضوعcancer
imidazoquinoxalines
imiquimod analogues
immunomodulation
parasitic infections
preclinical data
العنوانBiological applications of imiquimod analogues: An update (Review)
النوعArticle Review
رقم العدد3
رقم المجلد5
ESSN2632-2919
dc.accessType Open Access


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