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AuthorObeid, Joelle
AuthorShaito, Abdullah
AuthorHajj, Hiba El
AuthorDeleuze-Masquefa, Carine
AuthorBonnet, Pierre Antoine
AuthorEl-Sabban, Marwan
AuthorSaliba, Jessica
Available date2023-08-29T04:45:27Z
Publication Date2023-06-01
Publication NameWorld Academy of Sciences Journal
Identifierhttp://dx.doi.org/10.3892/wasj.2023.197
CitationObeid J, Shaito A, El Hajj H, Deleuze‑masquefa C, Bonnet P, El‑Sabban M and Saliba J: Biological applications of imiquimod analogues: An update (Review). World Acad Sci J 5: 20, 2023
ISSN26322900
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164812194&origin=inward
URIhttp://hdl.handle.net/10576/46856
AbstractThe last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of clinical trials, with only a handful being translated from the bench to bedside. One such example is imiquimod, an immune response modi‑ fier belonging to the imidazoquinoline family. Imiquimod was first approved by the US Food and Drug Administration for the topical treatment of anal and genital warts and actinic keratosis, and later exhibited a potent antitumor activity. This promising activity inspired the development of several imid‑ azoquinoxaline analogues and derivatives. The present review provides a comprehensive overview of the scientific literature on the chemical synthesis of imiquimod and several of its analogues, namely EAPB0203, EAPB0503 and EABP02303. The present review also discusses their preclinical proper‑ ties and mechanisms of action in the context of cancer and parasitic infections, highlighting the worthiness of translating these activities into therapeutic drugs.
Languageen
PublisherSpandidos Publications
Subjectcancer
imidazoquinoxalines
imiquimod analogues
immunomodulation
parasitic infections
preclinical data
TitleBiological applications of imiquimod analogues: An update (Review)
TypeArticle Review
Issue Number3
Volume Number5
ESSN2632-2919
dc.accessType Open Access


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