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المؤلفAlzaim, Ibrahim
المؤلفHammoud, Safaa H.
المؤلفAl-Koussa, Houssam
المؤلفGhazi, Alaa
المؤلفEid, Ali H.
المؤلفEl-Yazbi, Ahmed F.
تاريخ الإتاحة2023-08-31T15:18:30Z
تاريخ النشر2020-11-17
اسم المنشورFrontiers in Cardiovascular Medicine
المعرّفhttp://dx.doi.org/10.3389/fcvm.2020.602088
الاقتباسAlZaim, I., Hammoud, S. H., Al-Koussa, H., Ghazi, A., Eid, A. H., & El-Yazbi, A. F. (2020). Adipose tissue immunomodulation: a novel therapeutic approach in cardiovascular and metabolic diseases. Frontiers in Cardiovascular Medicine, 7, 602088.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096672543&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47143
الملخصAdipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, subcutaneous and visceral adipose tissues undergo marked hypertrophy and hyperplasia in response to nutritional excess leading to hypoxia, adipokine dysregulation, and subsequent low-grade inflammation that is characterized by increased infiltration and activation of innate and adaptive immune cells. The specific localization, physiology, susceptibility to inflammation and the heterogeneity of the inflammatory cell population of each adipose depot are unique and thus dictate the possible complications of adipose tissue chronic inflammation. Several lines of evidence link visceral and particularly perivascular, pericardial, and perirenal adipose tissue inflammation to the development of metabolic syndrome, insulin resistance, type 2 diabetes and cardiovascular diseases. In addition to the implication of the immune system in the regulation of adipose tissue function, adipose tissue immune components are pivotal in detrimental or otherwise favorable adipose tissue remodeling and thermogenesis. Adipose tissue resident and infiltrating immune cells undergo metabolic and morphological adaptation based on the systemic energy status and thus a better comprehension of the metabolic regulation of immune cells in adipose tissues is pivotal to address complications of chronic adipose tissue inflammation. In this review, we discuss the role of adipose innate and adaptive immune cells across various physiological and pathophysiological states that pertain to the development or progression of cardiovascular diseases associated with metabolic disorders. Understanding such mechanisms allows for the exploitation of the adipose tissue-immune system crosstalk, exploring how the adipose immune system might be targeted as a strategy to treat cardiovascular derangements associated with metabolic dysfunctions.
راعي المشروعThis work was supported by AUB-Faculty of Medicine Medical Practice Plan Grant No. 320148 and an AUB President Collaborative Research Stimulus Grant to AE-Y.
اللغةen
الناشرFrontiers Media
الموضوعAdipose tissue
Adipose tissue browning
Adipose tissue immunology
Adipose tissue inflammation-definition of metabolic syndrome-insulin resistance-myokines-systemic inflammation
Immunometabolism
العنوانAdipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases
النوعArticle
رقم المجلد7
ESSN2297-055X
dc.accessType Open Access


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