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المؤلفYounis, Nour K.
المؤلفZareef, Rana O.
المؤلفAl Hassan, Sally N.
المؤلفBitar, Fadi
المؤلفEid, Ali H.
المؤلفArabi, Mariam
تاريخ الإتاحة2023-09-03T07:13:56Z
تاريخ النشر2020-11-19
اسم المنشورFrontiers in Pharmacology
المعرّفhttp://dx.doi.org/10.3389/fphar.2020.597985
الاقتباسYounis, N. K., Zareef, R. O., Al Hassan, S. N., Bitar, F., Eid, A. H., & Arabi, M. (2020). Hydroxychloroquine in COVID-19 patients: pros and cons. Frontiers in Pharmacology, 11, 597985.
الرقم المعياري الدولي للكتاب1663-9812
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097251561&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47175
الملخصThe pandemic of COVID-19, caused by SARS-CoV-2, has recently overwhelmed medical centers and paralyzed economies. The unparalleled public distress caused by this pandemic mandated an urgent quest for an effective approach to manage or treat this disease. Due to their well-established anti-infectious and anti-inflammatory properties, quinine derivatives have been sought as potential therapies for COVID-19. Indeed, these molecules were originally employed in the treatment and prophylaxis of malaria, and later in the management of various autoimmune rheumatic and dermatologic diseases. Initially, some promising results for the use of hydroxychloroquine (HCQ) in treating COVID-19 patients were reported by a few in vitro and in vivo studies. However, current evidence is not yet sufficiently solid to warrant its use as a therapy for this disease. Additionally, the therapeutic effects of HCQ are not without many side effects, which range from mild gastrointestinal effects to life-threatening cardiovascular and neurological effects. In this review, we explore the controversy associated with the repurposing of HCQ to manage or treat COVID-19, and we discuss the cellular and molecular mechanisms of action of HCQ.
اللغةen
الناشرFrontiers Media S.A.
الموضوعchloroquine
COVID-19
drug discovery
drug repurposing
hydroxychloroquine
SARS-COV-2
العنوانHydroxychloroquine in COVID-19 Patients: Pros and Cons
النوعArticle
رقم المجلد11


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