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AuthorZupin, Luisa
AuthorCrovella, Sergio
AuthorMilena, Cadenaro
AuthorBarbi, Egidio
AuthorCelsi, Fulvio
Available date2023-09-10T05:03:25Z
Publication Date2023-09-01
Publication NameJournal of Biophotonics
Identifierhttp://dx.doi.org/10.1002/jbio.202300130
CitationZupin, L., Crovella, S., Milena, C., Barbi, E., Celsi, F., J. Biophotonics 2023, 16(9), e202300130. https://doi.org/10.1002/jbio.202300130
ISSN1864063X
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85162240977&origin=inward
URIhttp://hdl.handle.net/10576/47334
AbstractPhotobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. In this study, a possible molecular mechanism of the 905 nm PBMT (0.25 W/cm2; 3, 6, 12, and 18 J/cm2, 5 Hz) analgesic effect was tested on 50B11 cells, by investigating its impact on mitochondria. A decrement of adenosine triphosphate was detected, moreover, an increment of total reactive oxygen species and mitochondrial superoxide anion was found after PBMT with all protocols tested. PBMT at 18 J diminished the mitochondrial membrane potential, and influenced mitochondrial respiration, decreasing the oxygen consumption rate. Finally, a decrement of extracellular signal-regulated kinase 1/2 phosphorylation was observed with the protocol using 12 J. Taken together these findings highlighted the intracellular effects, mainly correlated to mitochondrial, induced by 905 nm PBMT in sensory neurons, indicating the central role of this organelle in the cellular response to 905 nm near-infrared laser light. (Figure presented.).
SponsorThis work was supported by the Italian Ministry of Health, through the contribution given to the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (RC 15/17 and RC 29/23).
Languageen
PublisherWiley
SubjectERK signaling
mitochondria
photobiomodulation therapy
sensory neurons
TitleThe mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
TypeArticle
Issue Number9
Volume Number16
ESSN1864-0648
dc.accessType Open Access


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