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المؤلفButnariu, M.
المؤلفQuispe, C.
المؤلفSharifi-Ra, J.
المؤلفPons-Fuste, E.
المؤلفLopez-Jorne, P.
المؤلفZam, W.
المؤلفDas, T.
المؤلفDey, A.
المؤلفKumar, M.
المؤلفPentea, M.
المؤلفEid, A.H.
المؤلفUmbetova, A.
المؤلفChen, J.-T.
تاريخ الإتاحة2023-09-18T09:52:25Z
تاريخ النشر2022
اسم المنشورFrontiers in Bioscience - Scholar
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.31083/j.fbs1403024
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47646
الملخصOral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends on cancer stage and location. As a result of the side effects of currently available drugs, there has been an increasing interest in the search for naturally-occurring bioactives for treating all types of cancer, including OC. Thus, this comprehensive review aims to give a holistic view on OC incidence and impact, while highlights the preclinical and clinical studies related to the use of medicinal plants for OC prevention and the recent developments in bioactive synthetic analogs towards OC management. Chemoprophylactic therapies connect the use of natural and/or synthetic molecules to suppress, inhibit or revert the transformation of oral epithelial dysplasia (DOK) into oral squamous cell carcinoma (OSCC). Novel searches have underlined the promising role of plant extracts and phytochemical compounds, such as curcumin, green tea extract, resveratrol, isothiocyanates, lycopene or genistein against this malignancy. However, poor bioavailability and lack of in vivo and clinical studies and complex pharmacokinetic profiles limit their huge potential of application. However, recent nanotechnological and related advances have shown to be promising in improving the bioavailability, absorption and efficacy of such compounds.
اللغةen
الناشرIMR Press Limited
الموضوعGuadecitabine
Cancer
Azacitidine
العنوانNaturally-Occurring Bioactives in Oral Cancer: Preclinical and Clinical Studies, Bottlenecks and Future Directions
النوعArticle
رقم العدد3
رقم المجلد14
dc.accessType Open Access


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