Identification of cortactin molecular forms in human urine and their possible diagnostic value
التاريخ
2021-07-01المؤلف
Starykovych, M.Souchelnytskyi, S.
Fayura, O.
Abrahamovych, O.
Abrahamovych, M.
Lukavetskyy, N.
Stoika, R.
Kit, Y.
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
The protein composition of human urine reflects changes in the biochemical and physiological status of an individual and has an essential diagnostic value. Using precipitation/extraction methods we isolated a protein with Mr ~100 kDa in a human urine. MALDI TOF/TOF mass spectrometry identified this protein as human Src protein kinase substrate cortactin (UniProtKB/Swiss-Prot: Q14247). Screening of urine samples using Western blotting with specific anti-human cortactin antibodies revealed different proteins immunologi-cally related to cortactin in healthy humans and patients with liver cirrhosis and lung cancer diseases. These data suggest that the level of cortacins isoform in urine might serve as a potential marker for testing acute and systemic diseases.
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