Browsing Biomedical Sciences by Title
Now showing items 413-432 of 685
-
The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals.
( MDPI , 2023 , Article)Healthy non-obese insulin resistant (IR) individuals are at higher risk of metabolic syndrome. The metabolic signature of the increased risk was previously determined. Physical activity can lower the risk of insulin ... -
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
( Impact Journals , 2017 , Article)Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based ... -
Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections
( MDPI , 2023 , Article Review)Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their ... -
Metagenomic Analysis of Oral Microbiome during pregnancy
( Qatar University Press , 2021 , Poster)Pregnancy is a dynamic physiological process associated with significant hormonal, immune and metabolic changes to support the growth and development of the fetus. Several studies have highlighted the role of gut microbiota ... -
Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
( Elsevier , 2023 , Article)Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
Microbiome profiling of rotavirus infected children suffering from acute gastroenteritis.
( BMC , 2021 , Report)Rotavirus (RV) is a leading cause of pediatric diarrhea and mortality worldwide. The virus causes acute gastroenteritis characterized by moderate to severe vomiting, diarrhea, dehydration, and fever. Microbial dysbiosis ... -
The Microbiota and Gut-Related Disorders: Insights from Animal Models
( MDPI , 2020 , Article Review)Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions ... -
Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex
( Elsevier , 2021 , Article)Microbe-derived acetate activates the Drosophila immunodeficiency (IMD) pathway in a subset of enteroendocrine cells (EECs) of the anterior midgut. In these cells, the IMD pathway co-regulates expression of antimicrobial ... -
microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review
( Elsevier , 2024 , Article)Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological ... -
MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.
( MDPI , 2019 , Article)Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ... -
MicroRNAs in Cardiac Hypertrophy
( MDPI AG , 2019 , Article Review)Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
( Wiley , 2019 , Article)This study aimed to analyze the potential association of different microRNA (miRNA) molecules with both type 2 diabetes (T2D) and obesity and determine their target genes. Quantitative PCR was used to analyze the miR-20b, ... -
miR-21 mimic blocks obesity in mice: A novel therapeutic option
( Elsevier , 2021 , Article)MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of ... -
Molecular analysis of the enteric protozoa associated with acute diarrhea in hospitalized children
( Frontiers Media S.A. , 2017 , Article)Pediatric diarrhea is a common cause of death among children under 5 years of age. In the current study, we investigated the frequency of intestinal parasites among 580 pediatric patients with chronic diarrhea. Parasitic ... -
Molecular and biological characterization of influenza A viruses isolated from human fecal samples
( Elsevier , 2021 , Article)Human influenza viruses are occasionally detected in the stools of influenza patients. Objectives: Here, we investigated the molecular and biological characteristics of intestinal influenza viruses and their potential role ... -
Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients
( Elsevier , 2023 , Book chapter)Colorectal cancer (CRC) is a form of cancer characterized by many symptoms and readily metastasizes to different organs in the body. Circadian rhythm is one of the many processes that is observed to be dysregulated in ... -
Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease.
( Taylor & Francis , 2020 , Article)Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiecncy of galactocerebrosidase (GALC) coding gene (). This ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ... -
Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation.
( Taylor & Francis , 2016 , Article)Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature survey showed that a residue exchange in ...
