Browsing Biomedical Sciences by Title
Now showing items 164-183 of 304
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Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
( Dove Medical Press , 2020 , Article)© 2020 Cheema et al. Objective: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study ... -
Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.
( Frontiers Media , 2019 , Article)Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. In the present ... -
An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD and Disulfiram.
( Wiley , 2019 , Article)Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram is the first approved drug by the Food and Drug Administration for alcohol-dependent patients, which targets the ALDH2 enzyme. Several ... -
The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
( Frontiers , 2021 , Article Review)The autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex ... -
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia
( Elsevier , 2020 , Article)Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the or genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. Here, we report a 2 year-old Egyptian boy with PA ... -
Investigation of the genetic structure of Kabyle and Chaouia Algerian populations through the polymorphism of Alu insertion markers
( Taylor and Francis Ltd , 2019 , Article)Background: In Algeria, as in all North Africa, Berbers constitute the old background of the population. Today, Berber speakers account for only ∼ 25% of Algerians. This decline is the product of a complex human settlement ... -
Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
( MDPI , 2020 , Article)(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has ... -
Iron shuttle chelation therapy enhances to reduce misplaced iron on secondary iron overloaded adult zebrafish
(2017 , Conference Paper)Thalassemia is the most common genetically inherited blood disorder in the world arises from defect in hemoglobin production, results in ineffective erythropoiesis and the rapid destruction of RBC in the periphery that ... -
iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes.
( American Chemical Society , 2012 , Article)The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with ... -
Laboratory challenges in the diagnosis of hepatitis E virus.
( Microbiology Society , 2018 , Article Review)Hepatitis E virus (HEV) is an RNA virus that is an important cause of both acute and chronic hepatitis worldwide. To date, there are eight HEV genotypes that can infect mammals. HEV-1 and HEV-2 infect exclusively humans, ... -
Macrophage Infection by Mycobacteria
( OMICS International , 2016 , Article)Mycobacterium tuberculosis is the etiological agent of tuberculosis. It is a pathogen that continues to draw international concerns particularly due to the emergence of multi-drug resistance and to the difficulties ... -
The march of pluripotent stem cells in cardiovascular regenerative medicine.
( BMC , 2018 , Article Review)Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ... -
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.
( MDPI , 2019 , Article)Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. is recognized ... -
Maternal microbiota regulate glucocorticoids levels and placental development in mice
( bioscientifica , 2015 , Conference Proceedings)The gut microbiota contributes to postnatal development and maturation by influencing barrier functions of the intestinal wall, the development of the immune system, and the utilisation of nutrients. Recent studies have ... -
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
( BioMed Central , 2016 , Article)Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ... -
Meta-analysis of the incidence of lead dislodgement with conventional and leadless pacemaker systems
( Blackwell Publishing Inc. , 2018 , Article Review)Introduction: Leadless cardiac pacemaker (LCP) implantation using a transcatheter was recently developed to avoid pocket- and lead-related complications. Although a LCP has an active fixation mechanism using tines or a ... -
Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
( Impact Journals , 2016 , Article)Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such ... -
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
( Impact Journals , 2017 , Article)Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based ... -
Microbiome profiling of rotavirus infected children suffering from acute gastroenteritis.
( BMC , 2021 , Report)Rotavirus (RV) is a leading cause of pediatric diarrhea and mortality worldwide. The virus causes acute gastroenteritis characterized by moderate to severe vomiting, diarrhea, dehydration, and fever. Microbial dysbiosis ... -
The Microbiota and Gut-Related Disorders: Insights from Animal Models
( MDPI , 2020 , Article Review)Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions ...
