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Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach.
(
Frontiers Media
, 2017 , Article)
Metformin is a commonly prescribed antihyperglycemic drug, and has been investigated in vivo and in vitro for its effect to improve the comorbidity of diabetes and various types of cancers. Several studies investigated the ...
CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion.
(2017 , Article)
We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling ...
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
(
BioMed Central
, 2016 , Article)
Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ...
Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
(
Longdom
, 2019 , Article)
Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in
transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant
association ...
Neutrophil Gelatinase Associated Lipocalin: Is not an Early Marker Inductor for Diabetic Nephropathy in Qatari Population
(
BJSTR
, 2019 , Article)
Background: The WHO Global Report on Diabetes (2016) showed that the number
of diabetic patients quadrupled between 1980 and 2016, while causing the death of 1.5
million people. While the global prevalence of diabetes ...
Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
(
Elsevier
, 2021 , Article)
The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles ...
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
(
Wiley Open Access
, 2020 , Article)
Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ...
Effect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy
(
MDPI
, 2020 , Article)
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, ...
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1
(
Public Library of Science
, 2020 , Article)
The SARS-CoV-2 (COVID-19) pandemic is a global crisis that threatens our way of life. As of November 18, 2020, SARS-CoV-2 has claimed more than 1,342,709 lives, with a global mortality rate of ~2.4% and a recovery rate of ...
Analytic comparison between three high-throughput commercial SARS-CoV-2 antibody assays reveals minor discrepancies in a high-incidence population
(
Nature Research
, 2021 , Article)
Performance of three automated commercial serological IgG-based assays was investigated for assessing SARS-CoV-2 "ever" (past or current) infection in a population-based sample in a high exposure setting. PCR and serological ...