Biomedical Sciences: المرسلات الحديثة
السجلات المعروضة 441 -- 460 من 802
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Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar’s experience
( International Society of Global Health , 2022 , Article)Background: The effective reproduction number, Rt, is a tool to track and understand epidemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset ... -
Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.
( Springer , 2022 , Article)SARS-CoV-2 breakthrough infections in vaccinated individuals and in those who had a prior infection have been observed globally, but the transmission potential of these infections is unknown. The RT-qPCR cycle threshold ... -
Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity.
( Frontiers Media , 2022 , Article)Increased COVID-19 disease severity is higher among patients with type 2 diabetes mellitus and hypertension. However, the metabolic pathways underlying this association are not fully characterized. This study aims to ... -
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 Infection.
( Frontiers Media , 2021 , Article)The COVID-19 pandemic has created an urgent situation throughout the globe. Therefore, it is necessary to identify the differentially expressed genes (DEGs) in COVID-19 patients to understand disease pathogenesis and the ... -
UNCONVENTIONAL ANIMAL MODELS IN INFECTIOUS DISEASE RESEARCH
( Frontiers , 2021 , Book)Apart from genetics and physiology, our understanding of other important aspects of the biological life, such as host-pathogen interactions stayed at its infancy for many years. Back then, many infectious diseases lacked ... -
One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar
( Frontiers , 2021 , Article)Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
Visible Light Photocatalytic Activity of Ag/WO3 Nanoparticles and its Antibacterial Activity Under Ambient Light and in The Dark
( Elsevier , 2022 , Article)Nanomaterial such as metals and metal oxide photocatalysts have emerged as important tools for removing contaminants from wastewater and as antibacterial agents to prevent infections; this is mainly due to their stability ... -
Comparison of antibody immune responses between BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in naïve and previously infected individuals.
( Oxford University Press , 2021 , Article)Two mRNA vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, obtained the Emergency Use Listing by WHO for preventing COVID-19. However, little is known about the difference in antibody responses induced by these two mRNA ... -
JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos
( Oxford University Press , 2021 , Article)Background: A sensitive method to investigate cellular stress and cytotoxicity is based on measuring mitochondrial membrane potential. Recently, JC-10, was developed to measure mitochondrial membrane potential in vitro and ... -
Severity, Criticality, and Fatality of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta Variant
( Oxford Academic , 2021 , Article)Beta (B.1.351) variant COVID-19 disease was investigated in Qatar. Compared to Alpha (B.1.1.7) variant, odds of progressing to severe disease were 1.24-fold (95% CI: 1.11-1.39) higher for Beta. Odds of progressing to ... -
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
( Elsevier , 2022 , Article)Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ... -
COVID-19 Vaccination: The Mainspring of Challenges and the Seed of Remonstrance
( MDPI , 2021 , Article Review)As of March 2020, the time when the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic, our existence has been threatened and the lives of ... -
Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
( Tech Science Press , 2022 , Article)The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant ... -
3D culture of cancer cells in alginate hydrogel beads as an effective technique for emergency cell storage and transportation in the pandemic era
( Wiley , 2021 , Article)Due to the restrictions in access to research lab during the pandemic time and due to existence of challenges in providing proper storage and transportation of cells in developing countries, having an effective and feasible ... -
Editorial: Unconventional Animal Models in Infectious Disease Research – Part I
( Frontiers Media , 2021 , Article)Editorial on the Research Topic Unconventional Animal Models in Infectious Disease Research -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( Hamad Bin Khalifa University Press , 2021 , Article)The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The spike ... -
Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants.
( Massachusetts Medical Society , 2021 , Other)The messenger RNA vaccine BNT162b2 (Pfizer–BioNTech) has 95% efficacy against coronavirus disease 2019 (Covid-19). Qatar launched a mass immunization campaign with this vaccine on December 21, 2020. As of March 31, 2021, ... -
Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
( Dovepress , 2021 , Article)Background: Hypertension (HT) is an idiopathic disease with severe complications and a high incidence of global mortality. Although the disease shares characteristic features with diabetes and obesity, the complex interplay ... -
Epidemiology Profile of Viral Meningitis Infections Among Patients in Qatar (2015-2018)
( Frontiers Media , 2021 , Article)Little is known about the etiology of meningitis in the MENA region, including Qatar. Viral agents are considered the major cause for meningitis worldwide. Here, we present primary data about the etiology and clinical and ...
