Biomedical Sciences: Recent submissions
Now showing items 241-260 of 775
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Molecular analysis of the enteric protozoa associated with acute diarrhea in hospitalized children
( Frontiers Media S.A. , 2017 , Article)Pediatric diarrhea is a common cause of death among children under 5 years of age. In the current study, we investigated the frequency of intestinal parasites among 580 pediatric patients with chronic diarrhea. Parasitic ... -
The genetic elucidation of monogenic obesity in the Arab world: a systematic review
( J Pediatr Endocrinol Metab , 2022 , Article)Background: Investigation of monogenic obesity (MO), a rare condition caused by a single gene variant(s), especially in consanguineous populations, is a powerful approach for obtaining novel insights into the genetic ... -
Design and synthesis of novel thioethers derived from 1,5-diphenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as antiangiogenic agents
( Bentham , 2018 , Article)Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening ... -
Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety
( Bentham , 2020 , Article)Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system ... -
Akkermansia, a possible microbial marker for poor glycemic control in qataris children consuming arabic diet—a pilot study on pediatric t1dm in qatar
( MDPI , 2021 , Article)In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, ... -
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
( Hindawi Limited , 2017 , Article)Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and ... -
The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis
( Wiley Blackwell , 2019 , Article Review)Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including ... -
The Therapeutic Role of Curcumin in Inflammation and Post-Surgical Outcomes
( Taylor and Francis Ltd. , 2023 , Article Review)Curcumin (diferuloylmethane) is a natural polyphenolic compound that targets multiple signaling molecules and helps in supporting health benefits as it aids in the management of oxidative and inflammatory conditions. ... -
Hemoglobin Oxidation in Stored Blood Accelerates Hemolysis and Oxidative Injury to Red Blood Cells.
( Thieme Gruppe , 2020 , Article)Maintaining blood supply is a challenge in blood banks. Red blood cells (RBCs) stored at 4°C experience issues of biochemical changes due to metabolism of cells, leading to changes collectively referred to as "storage ... -
Insights into the Middle Eastern paternal genetic pool in Tunisia: high prevalence of T-M70 haplogroup in an Arab population
( Nature Research , 2021 , Article)To obtain refreshed insights into the paternal lineages of Tunisian populations, Y-chromosome diversity was assessed in two populations belonging to an Arab genealogical lineage, Kairouan and Wesletia, as well as in four ... -
Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
( Portland Press Ltd , 2020 , Article Review)Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic ... -
Biochemical and cellular basis of oxidative stress: Implications for disease onset
( Wiley , 2023 , Article Review)Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ... -
Biological applications of imiquimod analogues: An update (Review)
( Spandidos Publications , 2023 , Article Review)The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ... -
3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
( Elsevier , 2023 , Article Review)Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized ... -
The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
( Nature Research , 2020 , Article)Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied ... -
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction
( Elsevier , 2020 , Article)Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's ... -
The hypertensive potential of estrogen: An untold story
( Elsevier , 2020 , Article Review)Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The implication of estrogen in this disease has been extensively studied. While the vast majority of published research argue for a ... -
A population study of clinically actionable genetic variation affecting drug response from the Middle East
( Nature Research , 2022 , Article)Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ... -
Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
( MDPI , 2022 , Article)Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection and growth. In addition to the known nutritional components of human breast milk (HBM), ... -
Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels
( American Chemical Society , 2022 , Article)Albumin-based hydrogels offer unique benefits such as biodegradability and high binding affinity to various biomolecules, which make them suitable candidates for biomedical applications. Here, we report a non-immunogenic ...
