Biomedical Sciences: Recent submissions
Now showing items 221-240 of 775
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The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
Population immunity of natural infection, primary-series vaccination, and booster vaccination in Qatar during the COVID-19 pandemic: an observational study
( Elsevier , 2023 , Article)BackgroundWaning of natural infection protection and vaccine protection highlight the need to evaluate changes in population immunity over time. Population immunity of previous SARS-CoV-2 infection or of COVID-19 vaccination ... -
Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections
(2023 , Article)In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ... -
Editorial: Unconventional animal models in infectious disease research, volume II
( Frontiers Media , 2023 , Article)Infectious diseases remain a serious health threat globally, an actuality that necessitates ongoing research in this field. Among different research modalities, the use of animal models to unravel host-pathogen interactions ... -
Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
( Elsevier , 2023 , Article)BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ... -
Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study
( Elsevier , 2023 , Article)BackgroundProtection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination ... -
Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-CoV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter
( Elsevier , 2023 , Article)RT-qPCR is considered the gold standard for diagnosis of COVID-19; however, it is laborious, time-consuming, and expensive. RADTs have evolved recently as relatively inexpensive methods to address these shortcomings, but ... -
Epac in vascular smooth muscle cells
( MDPI , 2020 , Article Review)Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process ... -
Traumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone
( MDPI , 2020 , Article Review)Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually ... -
The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy
( MDPI , 2020 , Article)Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ... -
Inflammatory basis of atherosclerosis: Modulation by sex hormones
( Bentham Science Publishers , 2021 , Article Review)Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Di-verse immune ... -
Repurposing cilostazol for raynaud's phenomenon
( Bentham Science Publishers , 2021 , Article Review)Raynaud's Phenomenon (RP) results from exaggerated cold-induced vasoconstriction. RP patients suffer from vasospastic attacks and compromised digital blood perfusion leading to a triple color change at the level the fingers. ... -
Drug repurposing in cancer: Now and beyond
(2021 , Article)No Abdtract -
Drug repurposing in neurodegenerative and cardiovascular diseases
( Bentham Science Publishers , 2021 , Article)No Abstract -
Characterization of neurobehavioral pattern in a zebrafish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model: A 96-hour behavioral study
( Public Library of Science , 2022 , Article)Parkinson’s disease (PD) is the most common brain motor disorder, characterized by a substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Motor impairments, such as dyskinesia, bradykinesia, ... -
The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar
( S. Karger AG , 2022 , Article)Introduction: Monogenic obesity (MO) is a rare genetic disease characterized by severe early-onset obesity in affected individuals. Previous genetic studies revealed 8 definitive genes for monogenic non-syndromic obesity; ... -
Seven novel glucose-6-phosphate dehydrogenase (G6PD) deficiency variants identified in the Qatari population
( BioMed Central Ltd , 2021 , Article)Background: Glucose-6-phosphate dehydrogenase deficiency (G6PDD) is the most common red cell enzymopathy in the world. In Qatar, the incidence of G6PDD is estimated at around 5%; however, no study has investigated the ... -
A cross-sectional study on the impact of the COVID-19 pandemic on psychological outcomes: Multiple indicators and multiple causes modeling
( Public Library of Science , 2022 , Article)Although the psychological impact of coronavirus disease 2019 (COVID-19) has been evaluated in the literature, further research is needed, particularly on post-traumatic stress disorder (PTSD) and psychological outcomes, ... -
Postprandial insulin and triglyceride concentrations are suppressed in response to breaking up prolonged sitting in Qatari females
( Frontiers Media S.A. , 2019 , Article)Background: Cultural, environmental and logistical factors challenge the Qatari population, particularly females, to engage in physical activity, and there is a high prevalence of diabetes in this population. Sedentary ... -
White Button Mushroom, Agaricus bisporus (Agaricomycetes), and a Probiotics Mixture Supplementation Correct Dyslipidemia without Influencing the Colon Microbiome Profile in Hypercholesterolemic Rats.
( Int J Med Mushrooms , 2020 , Article)Consumption of foods rich in dietary fiber has attracted considerable attention for lowering blood cholesterol and triglycerides through attenuation of gut microbiome. Diets rich in fiber may provide substrates for microbes ...
