عرض بسيط للتسجيلة

المؤلفDakroub, Ali
المؤلفA Nasser, Suzanne
المؤلفYounis, Nour
المؤلفBhagani, Humna
المؤلفAl-Dhaheri, Yusra
المؤلفPintus, Gianfranco
المؤلفEid, Assaad A.
المؤلفEl-Yazbi, Ahmed F.
المؤلفEid, Ali H.
تاريخ الإتاحة2023-10-10T10:23:53Z
تاريخ النشر2020-11-09
اسم المنشورCells
المعرّفhttp://dx.doi.org/10.3390/cells9112444
الاقتباسDakroub, A., A. Nasser, S., Younis, N., Bhagani, H., Al-Dhaheri, Y., Pintus, G., ... & Eid, A. H. (2020). Visfatin: A possible role in cardiovasculo-metabolic disorders. Cells, 9(11), 2444.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096083087&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48398
الملخصVisfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.
راعي المشروعThis research was funded by the American University of Beirut, grant number MPP320133 and Farouk Jabre Award (AHE) and by UAEU Program for Advanced Research, grant number 31S398-UPAR to Y.A.-D.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعmetabolic disorders
NAD+
PARPs/MARTs
sirtuins
visfatin/NAMPT
العنوانVisfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
النوعArticle
رقم العدد11
رقم المجلد9
ESSN2073-4409
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة