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AuthorDakroub, Ali
AuthorA Nasser, Suzanne
AuthorYounis, Nour
AuthorBhagani, Humna
AuthorAl-Dhaheri, Yusra
AuthorPintus, Gianfranco
AuthorEid, Assaad A.
AuthorEl-Yazbi, Ahmed F.
AuthorEid, Ali H.
Available date2023-10-10T10:23:53Z
Publication Date2020-11-09
Publication NameCells
Identifierhttp://dx.doi.org/10.3390/cells9112444
CitationDakroub, A., A. Nasser, S., Younis, N., Bhagani, H., Al-Dhaheri, Y., Pintus, G., ... & Eid, A. H. (2020). Visfatin: A possible role in cardiovasculo-metabolic disorders. Cells, 9(11), 2444.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096083087&origin=inward
URIhttp://hdl.handle.net/10576/48398
AbstractVisfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.
SponsorThis research was funded by the American University of Beirut, grant number MPP320133 and Farouk Jabre Award (AHE) and by UAEU Program for Advanced Research, grant number 31S398-UPAR to Y.A.-D.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectmetabolic disorders
NAD+
PARPs/MARTs
sirtuins
visfatin/NAMPT
TitleVisfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
TypeArticle
Issue Number11
Volume Number9
ESSN2073-4409
dc.accessType Open Access


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