Advanced adult granulosa cell tumor with prominent fibromatous stroma: A case report

Abstract

To the Editor, Adult granulosa cell tumor (AGCT) is the most common sex cord–stromal tumor and accounts for about 1% of all ovarian neoplasms.1 It is derived from granulosa cells of the ovarian follicle that are responsible for estradiol production and are admixed with a variable population of fibroblasts or theca cells. AGCT usually affects perimenopausal women (mean age ∼50–55 years).2 The patients present with abdominal pain or estrogenic manifestations (e.g., uterine bleeding).2 AGCTs tend to be unilateral, with solid and/or cystic growth patterns. Most patients present with stage I disease, associated with a 10-year survival rate of 90–95% and a recurrence rate of 10–15%; the overall recurrence rate for all stages combined is 20–30%. Extraovarian spread includes the peritoneum and omentum and rarely to the liver, lungs or bone.2,3 Tumors have many histologic patterns, while their stroma varies from scanty to abundant, which can be fibromatous or thecomatous.1,4