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المؤلفAlasmar, Reem Moath
المؤلفVaradharajan, Kavitha
المؤلفShanmugakonar, Muralitharan
المؤلفAl-Naemi, Hamda A.
تاريخ الإتاحة2023-11-30T08:13:11Z
تاريخ النشر2022-01-01
اسم المنشورMolecular Nutrition and Food Research
المعرّفhttp://dx.doi.org/10.1002/mnfr.202200322
الاقتباسAlasmar, R. M., Varadharajan, K., Shanmugakonar, M., & Al‐Naemi, H. A. (2022). Early‐Life Sugar Consumption Affects the Microbiome in Juvenile Mice. Molecular Nutrition & Food Research, 2200322.‏
الرقم المعياري الدولي للكتاب16134125
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85140018955&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49839
الملخصScope: The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term consumption of sugar influences the landscape of gut microbiota by altering the gut microbial population called dysbiosis. This study aims to evaluate the impact of long-term consumption of high sugar diet (HSD) on the diversity of gut microbiota. Methods and results: CD1 mice are given high concentration of sugar for 15 weeks followed by a recovery period of 10 weeks. Real-time polymerase chain reaction and 16S rRNA next-generation sequencing methods employ to identify microbiome diversity. The results show that Firmicutes and Bacteroidetes are the predominant phyla in control, cecum, and fecal samples. Firmicutes population are gradually increased in treated samples even after the recovery period, whereas Bacteroidetes abundance slightly reduces throughout the study. Conclusion: The present study shows that the impact of long period of high sugar diet consumption alters the diversity of normal gut flora which can be restored after 10 weeks of sugar withdrawal. This indicates that the intervention of healthy and nutritious diet influences gut microbes and this can be beneficial in reducing the implication of early life metabolic disorders such as obesity.
راعي المشروعThe authors would like to acknowledge LARC for their support and LARC vivarium team, for their support in animal care and husbandry. The research is funded by Qatar University.
اللغةen
الناشرJohn Wiley and Sons Inc
الموضوعCD1 mice
gut microbiota
high sugar diet (HSD)
next-generation sequencing (NGS)
real time-PCR
العنوانEarly-Life Sugar Consumption Affects the Microbiome in Juvenile Mice
النوعArticle
dc.accessType Open Access


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