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AuthorQueenie, Fernandes
AuthorTherachiyil, Lubna
AuthorKhan, Abdul Q.
AuthorBedhiafi, Takwa
AuthorKorashy, Hesham M
AuthorBhat, Ajaz A.
AuthorUddin, Shahab
Available date2024-01-29T11:01:03Z
Publication Date2023-09-19
Publication NameEuropean Journal of Pharmaceutical Sciences
Identifierhttp://dx.doi.org/10.1016/j.ejps.2023.106586
CitationFernandes, Q., Therachiyil, L., Khan, A. Q., Bedhiafi, T., Korashy, H. M., Bhat, A. A., & Uddin, S. (2023). Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells. European Journal of Pharmaceutical Sciences, 106586.
ISSN0928-0987
URIhttps://www.sciencedirect.com/science/article/pii/S0928098723002166
URIhttp://hdl.handle.net/10576/51326
AbstractCancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment leverages the unique optical, magnetic, and electrical attributes of nanomaterials to engineer innovative, targeted therapies. Specifically, manipulating nanomaterials allows for enhanced drug loading efficiency, improved bioavailability, and targeted delivery systems, reducing the non-specific cytotoxic effects characteristic of conventional chemotherapies. Furthermore, recent advances in nanotechnology have demonstrated encouraging results in specifically targeting CSCs, a key development considering the role of these cells in disease recurrence and resistance to treatment. Despite these breakthroughs, the clinical approval rates of nano-drugs have not kept pace with research advances, pointing to existing obstacles that must be addressed. In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.
SponsorOpen access is provided by Qatar National Library.
Languageen
PublisherElsevier
SubjectNanotherapy
Cancer stem cells
Signaling pathways
Pharmacokinetics
Drug resistance
TitleShrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
TypeArticle
Volume Number191
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1879-0720
dc.accessType Open Access


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