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The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities

Mehraj, Umar; Ganai, Rais A.; Macha, Muzafar A.; Hamid, Abid; Zargar, Mohammed A.; ... more authors ... less authors ( Springer , 2021 , Article Review)

Background: Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular ...

Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies

Nisar, Sabah; Bhat, Ajaz A.; Singh, Mayank; Karedath, Thasni; Rizwan, Arshi; ... more authors ... less authors ( Frontiers Media , 2021 , Article Review)

Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...

Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder

Yadav, Santosh K.; Bhat, Ajaz A.; Hashem, Sheema; Nisar, Sabah; Kamal, Madeeha; ... more authors ... less authors ( Springer Nature , 2021 , Article Review)

Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent pattern of inattentiveness, impulsiveness, restlessness, and hyperactivity. ...

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy

Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; ... more authors ... less authors ( BMC , 2021 , Article Review)

Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ...

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway

Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; ... more authors ... less authors ( Elsevier , 2021 , Article)

Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ...

Chemokine-cytokine networks in the head and neck tumor microenvironment

Nisar, Sabah; Yousuf, Parvaiz; Masoodi, Tariq; Wani, Nissar A.; Hashem, Sheema; ... more authors ... less authors ( MDPI , 2021 , Article Review)

Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...

Brain Microstructural Changes Support Cognitive Deficits in Normal Children Born to HIVinfected Mothers

Santosh Kumar Yadav, Rakesh K Gupta , Sabah N Ahmed , Sheema Hashem , Ajaz A Bhat , Ravindra K Garg , Vimala Venkatesh , Muhammad W Azeem , and Mohammad Haris.; Yadav, Santosh Kumar; Gupta, Rakesh K; Ahmed, Sabah N; Hashem, Sheema; ... more authors ... less authors (2018 , Conference)

Synopsis In the current study, we evaluated the brain integrity [by mapping the fractional anisotropy (FA) and mean diffusivity (MD)] and neurocognitive performance (NP) in normal children (NCI) born to HIV-infected ...

miRNAs as novel immunoregulators in cancer

Lone, Saife N.; Bhat, Ajaz A.; Wani, Nissar A.; Karedath, Thasni; Hashem, Sheema; ... more authors ... less authors ( Elsevier , 2021 , Article Review)

The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...