Now showing items 1-4 of 4
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)
Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ...
CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship
( Nature , 2017 , Article)
The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic ...
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
( American Association For Laboratory Animal Science , 2017 , Poster)
Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ...
Effect of psoriasis linked CARMA2sh gene in transgenic animal model
(2018 , Poster)
Background • CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB, that has a central role in controlling the immune and inflammatory response, cell survival and ...