Laboratory Animal Research Center (Research): المرسلات الحديثة
السجلات المعروضة 81 -- 97 من 97
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Effect of psoriasis linked CARMA2sh gene in transgenic animal model
(2018 , Poster)Background • CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB, that has a central role in controlling the immune and inflammatory response, cell survival and ... -
Humane care and use of laboratory animals training program (HCULA)
(2017 , Poster)HCULA is the first basic training program that covers the use of Rodents as animals models in biomedical research, it is composed of theory and hands on training courses . The theory course is required to all students ... -
RAS-mediated oncogenic signaling pathways in human malignancies
( Elsevier , 2018 , Article Review)Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ... -
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
( American Association For Laboratory Animal Science , 2017 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ... -
SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle
( Wiley , 2017 , Article)Silent mating type information regulation 2 homologue 1 (SIRT1) activity and content increased significantly in overload-induced hypertrophy. SIRT1-mediated signalling through Akt, the endothelial nitric oxide synthase ... -
The physiological effects of concurrent strength and endurance training sequence: A systematic review and meta-analysis.
( Taylor & Francis , 2017 , Article Review)We conducted a systematic literature review and meta-analysis to assess the chronic effects of the sequence of concurrent strength and endurance training on selected important physiological and performance parameters, ... -
Real-Time PCR Quantification of Metallothionein Gene Expression in Sprague–Dawley Rats Chronically Exposed to Cd
( American Association for Laboratory Animal Science , 2012 , Presentation)Toxicologic impact of Cd leads to multiple human pathologic conditions, and its effect on humans and animals has been extensively studied. Physiologic function of metallothionein (MT1) is not completely understood, but ... -
A Novel Mutation (Q694X) in the ITGB3 Gene Causing Glanzmann’s Thrombasthenia from the Sultanate of Oman
( The American Society of Hematology , 2008 , Article)Background: Glanzmann Thrombasthenia (GT) results from mutations in the genes ITGA2B and ITGB3, located on chromosome 17q21–23 which encodes the platelet glycoprotein αIIbβ3 complex, namely GPIIb (αIIb) and GPIIIa (β3), ... -
Animal Health Monitoring Program (AHMP) of LARC
(2017 , Poster)Animal health monitoring is important to maintain the health of the animals used for research purpose. Maintaining healthy research animals is the prime requisite for best research outcomes. Health monitoring is performed ... -
Diagnostic Microbiology Laboratory Monitoring of LARC
(2017 , Poster)Microbial free environment of a research facility is critical to maintain animal health. Establishing Microbiological Monitoring Program is mandatory to assure the quality of the system. Microbiological monitoring involves ... -
Environmental Health Monitoring Program (EHMP) of LARC
(2017 , Poster)Routine environmental monitoring is the prime necessity to maintain a Specific Pathogen Free (SPF) facility. Monitoring the animals & its environment is important to control the contamination and outbreak of disease. ... -
ANIMAL MODEL FOR CHILDHOOD OBESITY
(2017 , Poster)Obesity has been recognized as a global health problem and linked with chronic diseases such as diabetes mellitus, cardiovascular syndromes, musculoskeletal disorders and some cancers. Children exposed to high carbohydrate, ... -
Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
(2017 , Poster)CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ... -
ENDOTHELIAL NITRIC OXIDE ACTIVITY & BIOAVAILABILITY DURING OBESITY CONDITIONS
(2017 , Poster)Obesity has been recognized as a pandemic and linked with several metabolic dysfunctions. One of the hallmarks in the onset of obesity is the development of hypertension coupled with endothelial dysfunction. (ED) A fundamental ... -
CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship
( Nature , 2017 , Article)The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic ... -
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ... -
NF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
( American Society for Biochemistry and Molecular Biology , 2016 , Article)The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis ...