عرض بسيط للتسجيلة

المؤلفReale, Carla
المؤلفIervolino, Anna
المؤلفScudiero, Ivan
المؤلفFerravante, Angela
المؤلفEgildo D, Luca
المؤلفMazzone, Pellegrino
المؤلفZotti, Tiziana
المؤلفLeonardi, Antonio
المؤلفRoberto, Luca
المؤلفZannini, Mariastella
المؤلفCristofaro, Tiziana de
المؤلفShanmugakona, Muralitharan
المؤلفCapasso, Giovambattista
المؤلفPasparakis, Manolis
المؤلفVito, Pasquale
المؤلفStilo, Romania
تاريخ الإتاحة2017-03-01T06:50:19Z
تاريخ النشر2016-03-11
اسم المنشورJournal of Biological Chemistry
المعرّفhttp://dx.doi.org/10.1074/jbc.M115.711697
الاقتباسManolis Pasparakis, Pasquale Vito and Romania Stilo Zannini, Tiziana De Cristofaro, Muralitharan Shanmugakonar, Giovambattista Capasso, Pellegrino Mazzone, Tiziana Zotti, Antonio Leonardi, Luca Roberto, Mariastella Carla Reale, Anna Iervolino, Ivan Scudiero, Angela Ferravante, Luca Egildo D'Andrea, NF-kB Essential MOdulator (NEMO) Is Critical for Thyroid Function J. Biol. Chem. published online January 19, 2016
الرقم المعياري الدولي للكتاب0021-9258
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5323
الملخصThe I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis and apoptosis. To explore the functional role of canonical NF-κB signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knockout mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.
اللغةen
الناشرAmerican Society for Biochemistry and Molecular Biology
الموضوعNF-kappaB (NF-κB)
NEMO, thyroid
transgenic mice
knockout
thyroid hormone
apoptosis
العنوانNF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
النوعArticle
الصفحات5765-5773
ESSN1083-351X
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة