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AuthorShanmugakonar, Muralitharan
AuthorVaradharajan, Kavitha
AuthorVito, Pasquale
Available date2017-05-14T06:55:36Z
Publication Date2017-05-03
CitationShanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale "Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells" Qatar University Annual Research Forum (2017), Doha May 3-4
URIhttp://hdl.handle.net/10576/5492
AbstractCARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. CARMA2short (CARMA2sh) which is the most prominent CARMA2 isoform expressed in human keratinocytes. It has already been identified that CARMA2sh induces activation of NF-κB, and this activity requires the function of another CARD-containing protein, namely BCL10, and the adapter protein TRAF2. This study identified a CARMA Inhibitory Kinase (CIK) which inhibit the ability to induce NF-κB. CIK is not tested for their function in Human Primary keratinocytes and hence we attempt to understand the function of CIK and its associated molecules by invitro and invivo models. The inhibitory activity of CIK on CARMA2 in primary human keratinocytes expressing wild (wt) & mutant CARMA2 was analyzed.
SponsorThis work was made possible by NPRP grant NPRP 7 - 466 - 3119 from the Qatar National Research Fund of Qatar Foundation
Languageen
SubjectTransgenic mice
SubjectCARMA 2sh
SubjectES cells
SubjectNHEK
SubjectRT-PCR
TitleEffect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
TypePoster


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