Browsing Biomedical Research Center by Author "Vranic, Semir"
Now showing items 1-16 of 16
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Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
Allouch, Soumaya; Gupta, Ishita; Malik, Shaza; Al Farsi, Halema F; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Co-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.
Al-Thawadi, Hamda; Ghabreau, Lina; Aboulkassim, Tahar; Yasmeen, Amber; Vranic, Semir; Batist, Gerald; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2018 , Article)Epstein-Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression ... -
Co-presence of human papillomaviruses and Epstein-Barr virus is linked with advanced tumor stage: a tissue microarray study in head and neck cancer patients.
Al-Thawadi, Hamda; Gupta, Ishita; Jabeen, Ayesha; Skenderi, Faruk; Aboulkassim, Tahar; Yasmeen, Amber; Malki, Mohammed I; Batist, Gerald; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2020 , Article)Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this fact, we ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
Mahmoud, Nouf N.; Zakaria, Zain Zaki; Kheraldine, Hadeel; Gupta, Ishita; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala Eddin Al... more authors ... less authors ( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Fascin in Gynecological Cancers: An Update of the Literature
Gupta, Ishita; Vranic, Semir; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin ( MDPI , 2021 , Article)Fascin is an actin-binding protein that is encoded by the gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different ... -
High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions
Allouch, Soumaya; Malki, Ahmed; Allouch, Asma; Gupta, Ishita; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Cervical cancer is the fourth most common malignancy in women worldwide and a leading cause of cancer-related mortality in developing countries. Important etiological factors in this cancer are high-risk human papillomaviruses ... -
High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.
Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; AlAhmad, Yaman M; Al Moustafa, Ala-Eddin; Vranic, Semir... more authors ... less authors ( MDPI , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
High-risk human papillomaviruses and epstein–barr virus in colorectal cancer and their association with clinicopathological status
Gupta, Ishita; Farsi, Halema Al; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; Alahmad, Yaman M.; Moustafa, Ala Eddin Al; Vranic, Semir... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
Gupta, Ishita; Jabeen, Ayesha; Vranic, Semir; Al Moustafa, Ala-Eddin; Al-Thawadi, Hamda ( Frontiers Media , 2021 , Article)Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ... -
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ... -
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
Vranic, Semir; Cyprian, Farhan Sachal; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ... -
SARS-CoV-2 Infection and Smoking: What is the association? A brief review
Ishita, Gupta; Sohail, Muhammad Umar; Elzawawi, Khaled E.; Amarah, Ahmed H.; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala-Eddin Al... more authors ... less authors ( Elsevier , 2021 , Article)Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ... -
Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.
Al-Qahdi, Shaikha S; Alzohari, Nada; Alsaid, Abrar Y; Ashour, Anas A; Aboulkassim, Tahar; Vranic, Semir; Al Moustafa, Ala-Eddin; Khalil, Ashraf A... more authors ... less authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the ... -
Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
Gupta, Ishita; Sareyeldin, Rasha M.; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2019 , Article)Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ... -
Water-pipe smoking promotes epithelial-mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways.
Sadek, Khaled W; Haik, Mahmoud Y; Ashour, Anas A; Baloch, Tahira; Aboulkassim, Tahar; Yasmeen, Amber; Vranic, Semir; Zeidan, Asad; Al Moustafa, Ala-Eddin... more authors ... less authors ( BioMed Central Ltd. , 2018 , Article)With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women's health. The main goal of this study is to identify the potential outcome of WPS on human breast cancer ...