Browsing Biomedical Research Center by Title
Now showing items 432-451 of 733
-
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
( BMC , 2019 , Article)Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. ... -
Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity.
( Frontiers Media , 2022 , Article)Increased COVID-19 disease severity is higher among patients with type 2 diabetes mellitus and hypertension. However, the metabolic pathways underlying this association are not fully characterized. This study aims to ... -
The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals.
( MDPI , 2023 , Article)Healthy non-obese insulin resistant (IR) individuals are at higher risk of metabolic syndrome. The metabolic signature of the increased risk was previously determined. Physical activity can lower the risk of insulin ... -
Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight
( Frontiers Media , 2021 , Article)Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile ... -
Metabolomic profiling reveals key metabolites associated with hypertension progression
( Frontiers Media SA , 2024 , Article)Introduction: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for ... -
Metabolomics and doping analysis: promises and pitfalls.
( Future Science , 2020 , Article)This brief commentary presents an overview of the potential utility of metabolomics-based approaches in doping analysis, with particular emphasis on areas where the current analytical procedures would most benefit from ... -
Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections
( MDPI , 2023 , Article Review)Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their ... -
Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids.
( Endocrine Society , 2020 , Article)The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ... -
Metabolomics Profiling of Stages of Coronary Artery Disease Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are ... -
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
( MDPI , 2022 , Article)Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics ... -
Metagenomic analysis demonstrates the diversity of the fecal virome in asymptomatic pigs in East Africa
( Springer Vienna , 2016 , Article)Pigs harbor a variety of viruses that are closely related to human viruses and are suspected to have zoonotic potential. Little is known about the presence of viruses in smallholder farms where pigs are in close contact ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
Microbiome engineering to combat antimicrobial resistance and upsurge productivity of food animals: a systematic review
( CSIRO Publishing , 2022 , Article)Extensive antimicrobial usage in animal farming plays a prominent role in the antimicrobial resistance (AMR) crisis and is repeatedly highlighted as an area needing development under the ‘One Health’ approach. Alternative ... -
Microfluidic-based virus detection methods for respiratory diseases
( Springer , 2021 , Article)With the recent SARS-CoV-2 outbreak, the importance of rapid and direct detection of respiratory disease viruses has been well recognized. The detection of these viruses with novel technologies is vital in timely prevention ... -
Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications
( Multidisciplinary Digital Publishing Institute (MDPI) , 2015 , Article)A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. ... -
MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.
( MDPI , 2019 , Article)Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ... -
Minimally Invasive and Non-Invasive Technologies for Predicting Heart Failure
( Wiley , 2022 , Book chapter)Heart failure is a life-threatening medical problem which refers to inadequate blood supply to body tissues due to the limited functioning of heart muscles. Heart failure is mostly observed as a chronic disease which ... -
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
( Elsevier , 2022 , Article)Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ... -
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children
( Nature Publishing Group , 2019 , Article)Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Infection can be caused ... -
Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.
( Nature Research , 2019 , Article)Acute gastroenteritis remains a major cause of morbidity and mortality among young children worldwide. It accounts for approximately 1.34 million deaths annually in children younger than five years. Infection can be caused ...