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AuthorAlahmad, Yaman M
AuthorAljaber, Mohammed
AuthorSaleh, Alaaeldin I
AuthorYalcin, Huseyin C
AuthorAboulkassim, Tahar
AuthorYasmeen, Amber
AuthorBatist, Gerald
AuthorMoustafa, Ala-Eddin Al
Available date2018-06-27T06:14:53Z
Publication Date2018-05-01
Publication NameHead and Necken_US
CitationAlahmad YM, Aljaber M, Saleh AI, et al. Effect of cell‐phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells. Head & Neck. 2018;00:1–6.
AbstractToday, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored. The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes. Our data revealed that cell-phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E-cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models. Our investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation.
SponsorThis work was supported by Qatar University and GCC grant #2017‐002 QU/KU
Subjectcancer progression
Subjectcell invasion
Subjectcell phone
TitleEffect of cell-phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells.

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