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المؤلفAl-Thawadi, Hamda
المؤلفGhabreau, Lina
المؤلفAboulkassim, Tahar
المؤلفYasmeen, Amber
المؤلفVranic, Semir
المؤلفBatist, Gerald
المؤلفAl Moustafa, Ala-Eddin
تاريخ الإتاحة2019-03-31T08:43:20Z
تاريخ النشر2018-07-02
اسم المنشورFrontiers in Oncology
المعرّفhttp://dx.doi.org/10.3389/fonc.2018.00250
الاقتباسAl-Thawadi H, Ghabreau L, Aboulkassim T, Yasmeen A, Vranic S, Batist G and Al Moustafa A-E (2018) Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women. Front. Oncol. 8:250. doi: 10.3389/fonc.2018.00250
المعرّفArticle # 250
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11463
الملخصEpstein-Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression of this cancer. Accordingly, our group has recently viewed the presence and genotyping distribution of high-risk HPVs in cervical cancer in Syrian women; our data pointed out that HPVs are present in 42/44 samples (95%). Herein, we aim to explore the co-prevalence of EBV and high-risk HPVs in 44 cervical cancer tissues from Syrian women using polymerase chain reaction, immunohistochemistry, and tissue microarray analyses. We found that EBV and high-risk HPVs are co-present in 15/44 (34%) of the samples. However, none of the samples was exclusively EBV-positive. Additionally, we report that the co-expression of LMP1 and E6 genes of EBV and high-risk HPVs, respectively, is associated with poorly differentiated squamous cell carcinomas phenotype; this is accompanied by a strong and diffuse overexpression of Id-1 (93% positivity), which is an important regulator of cell invasion and metastasis. These data imply that EBV and HPVs are co-present in cervical cancer samples in the Middle East area including Syria and their co-presence is associated with a more aggressive cancer phenotype. Future investigations are needed to elucidate the exact role of EBV and HPVs cooperation in cervical carcinogenesis.
راعي المشروعWe would like to thank Mrs. A. Kassab for her critical reading of the manuscript. This work was supported by Qatar University grants # GCC-2017-002 QU/KU and QUCG-CMED-2018\2019-3.
اللغةen
الناشرFrontiers Media
الموضوعEpstein–Barr virus
Syrian women
cancer phenotype
cervical cancer
high-risk human papillomaviruses
العنوانCo-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.
النوعArticle
رقم المجلد8
ESSN2234-943X
dc.accessType Open Access


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