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AuthorAl-Thawadi, Hamda
AuthorGhabreau, Lina
AuthorAboulkassim, Tahar
AuthorYasmeen, Amber
AuthorVranic, Semir
AuthorBatist, Gerald
AuthorAl Moustafa, Ala-Eddin
Available date2019-03-31T08:43:20Z
Publication Date2018-07-02
Publication NameFrontiers in Oncology
Identifierhttp://dx.doi.org/10.3389/fonc.2018.00250
CitationAl-Thawadi H, Ghabreau L, Aboulkassim T, Yasmeen A, Vranic S, Batist G and Al Moustafa A-E (2018) Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women. Front. Oncol. 8:250. doi: 10.3389/fonc.2018.00250
IdentifierArticle # 250
URIhttp://hdl.handle.net/10576/11463
AbstractEpstein-Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression of this cancer. Accordingly, our group has recently viewed the presence and genotyping distribution of high-risk HPVs in cervical cancer in Syrian women; our data pointed out that HPVs are present in 42/44 samples (95%). Herein, we aim to explore the co-prevalence of EBV and high-risk HPVs in 44 cervical cancer tissues from Syrian women using polymerase chain reaction, immunohistochemistry, and tissue microarray analyses. We found that EBV and high-risk HPVs are co-present in 15/44 (34%) of the samples. However, none of the samples was exclusively EBV-positive. Additionally, we report that the co-expression of LMP1 and E6 genes of EBV and high-risk HPVs, respectively, is associated with poorly differentiated squamous cell carcinomas phenotype; this is accompanied by a strong and diffuse overexpression of Id-1 (93% positivity), which is an important regulator of cell invasion and metastasis. These data imply that EBV and HPVs are co-present in cervical cancer samples in the Middle East area including Syria and their co-presence is associated with a more aggressive cancer phenotype. Future investigations are needed to elucidate the exact role of EBV and HPVs cooperation in cervical carcinogenesis.
SponsorWe would like to thank Mrs. A. Kassab for her critical reading of the manuscript. This work was supported by Qatar University grants # GCC-2017-002 QU/KU and QUCG-CMED-2018\2019-3.
Languageen
PublisherFrontiers Media
SubjectEpstein–Barr virus
Syrian women
cancer phenotype
cervical cancer
high-risk human papillomaviruses
TitleCo-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.
TypeArticle
Volume Number8
ESSN2234-943X
dc.accessType Open Access


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