Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
![Thumbnail](/xmlui/bitstream/handle/10576/13472/s12943-020-01175-9.pdf.jpg?sequence=5&isAllowed=y)
عرض / فتح
التاريخ
2020-03-01المؤلف
Bhat, Ajaz AYounes, Salma N
Raza, Syed Shadab
Zarif, Lubna
Nisar, Sabah
Ahmed, Ikhlak
Mir, Rashid
Kumar, Sachin
Sharawat, Surender K
Hashem, Sheema
Elfaki, Imadeldin
Kulinski, Michal
Kuttikrishnan, Shilpa
Prabhu, Kirti S
Khan, Abdul Q
Yadav, Santosh K
El-Rifai, Wael
Zargar, Mohammad A
Zayed, Hatem
Haris, Mohammad
Uddin, Shahab
...show more authors ...show less authors
البيانات الوصفية
عرض كامل للتسجيلةالملخص
Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.
المجموعات
- العلوم الحيوية الطبية [692 items ]
- الأبحاث [96 items ]