Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
View/ Open
Date
2019Author
Sareyeldin, Rasha M.Gupta, Ishita
Al-Hashimi, Israa
Al-Thawadi, Hamda A.
Al Farsi, Halema F.
Vranic, Semir
Al Moustafa, Ala-Eddin
...show more authors ...show less authors
Metadata
Show full item recordAbstract
Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15-20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.
Collections
- Biomedical Research Center Research [735 items ]
- Medicine Research [1448 items ]