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AuthorAllouch, Soumaya
AuthorMalki, Ahmed
AuthorAllouch, Asma
AuthorGupta, Ishita
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
Available date2020-07-29T22:27:00Z
Publication Date2020-06-30
Publication NameFrontiers in Oncology
Identifierhttp://dx.doi.org/10.3389/fonc.2020.00914
CitationAllouch S, Malki A, Allouch A, Gupta I, Vranic S and Al Moustafa A-E (2020) High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions. Front. Oncol. 10:914. doi: 10.3389/fonc.2020.00914
URIhttp://hdl.handle.net/10576/15404
AbstractCervical cancer is the fourth most common malignancy in women worldwide and a leading cause of cancer-related mortality in developing countries. Important etiological factors in this cancer are high-risk human papillomaviruses (HPV), as roughly 96% of cervical cancer cases are positive for these oncoviruses. On the other hand, it has been recently pointed out that E6/E7 oncoproteins of high-risk HPV can upregulate the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis. Likewise, several recent reports showed that checkpoint blockades targeting PD-1/PD-L1 pathways have achieved efficient clinical responses via suppressing cancer progression and improving survival in several types of human cancers including metastatic cervical cancer. In this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway and its interaction with high-risk HPV and their oncoproteins, which could have an important impact on the management of HPV-associated cancers including cervical.
SponsorQatar University: QUHICMED-19/20-1, GCC # 2017-002 QU/KU, and QUST-1-CMED2020-2.
Languageen
PublisherFrontiers Media
SubjectPD-1/PD-L1
cervical cancer
high-risk HPV
immunotherapy
oncoproteins
TitleHigh-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions
TypeArticle
Volume Number10
ESSN2234-943X
dc.accessType Open Access


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