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AuthorAl-Thani, Hissa F
AuthorShurbaji, Samar
AuthorYalcin, Huseyin C
Available date2021-07-07T05:29:38Z
Publication Date2021-06-28
Publication NamePharmaceuticals
Identifierhttp://dx.doi.org/10.3390/ph14070625
CitationAl-Thani, H.F.; Shurbaji, S.; Yalcin, H.C. Zebrafish as a Model for Anticancer Nanomedicine Studies. Pharmaceuticals 2021, 14, 625. https://doi.org/10.3390/ph14070625
URIhttp://hdl.handle.net/10576/21328
AbstractNanomedicine is a new approach to fight against cancer by the development of anticancer nanoparticles (NPs) that are of high sensitivity, specificity, and targeting ability to detect cancer cells, such as the ability of Silica NPs in targeting epithelial cancer cells. However, these anticancer NPs require preclinical testing, and zebrafish is a useful animal model for preclinical studies of anticancer NPs. This model affords a large sample size, optical imaging, and easy genetic manipulation that aid in nanomedicine studies. This review summarizes the numerous advantages of the zebrafish animal model for such investigation, various techniques for inducing cancer in zebrafish, and discusses the methods to assess cancer development in the model and to test for the toxicity of the anticancer drugs and NPs. In addition, it summarizes the recent studies that used zebrafish as a model to test the efficacy of several different anticancer NPs in treating cancer.
SponsorThis study was supported by a Qatar University Student Grant (QUST-2-CHS-2020-11). The publication of this article was funded by the Qatar National Library (QNL).
Languageen
PublisherMDPI
Subjectcancer
nanomedicine
nanoparticle
pre-clinical
zebrafish
TitleZebrafish as a Model for Anticancer Nanomedicine Studies.
TypeArticle Review
Issue Number7
Volume Number14
ESSN1424-8247
dc.accessType Open Access


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