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AuthorGupta, Ishita
AuthorVranic, Semir
AuthorAl-Thawadi, Hamda
AuthorAl Moustafa, Ala-Eddin
Available date2021-11-29T11:14:24Z
Publication Date2021-11-17
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers13225760
CitationGupta, I.; Vranic, S.; Al-Thawadi, H.; Al Moustafa, A.-E. Fascin in Gynecological Cancers: An Update of the Literature. Cancers 2021, 13, 5760. https://doi.org/10.3390/cancers13225760
Identifier5760
URIhttp://hdl.handle.net/10576/25191
AbstractFascin is an actin-binding protein that is encoded by the gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression correlated with tumor growth, migration, invasion, and metastasis. Moreover, overexpression of fascin was found in oncovirus-infected cells, such as human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), disrupting the cell-cell adhesion and enhancing cancer progression. Based on these findings, several studies reported fascin as a potential biomarker and a therapeutic target in various cancers. This review provides a brief overview of the FSCN1 role in various cancers with emphasis on gynecological malignancies. We also discuss fascin interactions with other genes and oncoviruses through which it might induce cancer development and progression.
Languageen
PublisherMDPI
Subjectbiomarker
cervical cancer
fascin
gynecological cancer
ovarian cancer
TitleFascin in Gynecological Cancers: An Update of the Literature
TypeArticle
Issue Number22
Volume Number13
dc.accessType Open Access


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