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AuthorElrayess, Mohamed A
AuthorCyprian, Farhan S
AuthorAbdallah, Abdallah M
AuthorEmara, Mohamed M
AuthorDiboun, Ilhame
AuthorAnwardeen, Najeha
AuthorSchuchardt, Sven
AuthorYassine, Hadi M
Available date2022-01-30T06:00:20Z
Publication Date2022
Publication NameFrontiers in Medicine
Identifierhttp://dx.doi.org/10.3389/fmed.2021.788687
CitationElrayess MA, Cyprian FS, Abdallah AM, Emara MM, Diboun I, Anwardeen N, Schuchardt S and Yassine HM (2022) Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity. Front. Med. 8:788687. doi: 10.3389/fmed.2021.788687
URIhttp://hdl.handle.net/10576/26043
AbstractIncreased COVID-19 disease severity is higher among patients with type 2 diabetes mellitus and hypertension. However, the metabolic pathways underlying this association are not fully characterized. This study aims to identify the metabolic signature associated with increased COVID-19 severity in patients with diabetes mellitus and hypertension. One hundred and fifteen COVID-19 patients were divided based on disease severity, diabetes status, and hypertension status. Targeted metabolomics of serum samples from all patients was performed using tandem mass spectrometry followed by multivariate and univariate models. Reduced levels of various triacylglycerols were observed with increased disease severity in the diabetic patients, including those containing palmitic (C16:0), docosapentaenoic (C22:5, DPA), and docosahexaenoic (C22:6, DHA) acids (FDR < 0.01). Functional enrichment analysis revealed triacylglycerols as the pathway exhibiting the most significant changes in severe COVID-19 in diabetic patients (FDR = 7.1 × 10). Similarly, reduced levels of various triacylglycerols were also observed in hypertensive patients corresponding with increased disease severity, including those containing palmitic, oleic (C18:1), and docosahexaenoic acids. Functional enrichment analysis revealed long-chain polyunsaturated fatty acids (n-3 and n-6) as the pathway exhibiting the most significant changes with increased disease severity in hypertensive patients (FDR = 0.07). Reduced levels of triacylglycerols containing specific long-chain unsaturated, monounsaturated, and polyunsaturated fatty acids are associated with increased COVID-19 severity in diabetic and hypertensive patients, offering potential novel diagnostic and therapeutic targets.
SponsorThis research was funded by the Qatar National Research Fund, Grant Number NPRP11S-1212-170092.
Languageen
PublisherFrontiers Media
SubjectCOVID-19
diabetes mellitus
docosahexaenoic acid
docosapentaenoic acid
hypertension
oleic acid
palmitic acid
triacylglycerols
TitleMetabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity.
TypeArticle
Volume Number8
ESSN2296-858X
dc.accessType Open Access


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