Browsing Medicine Research by Author "Taleb, Sara"
Now showing items 1-6 of 6
-
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
Nasarallah, Gheyath K.; Fakhroo, Aisha D.; Khan, Taushif; Cyprian, Farhan S.; Al Ali, Fatima; Ata, Manar M.A.; Taleb, Sara; Zedan, Hadeel T.; Al-Sadeq, Duaa W.; Amanullah, Fathima H.; Hssain, Ali A.; Eid, Ali H.; Abu-Raddad, Laith J.; Al-Khal, Abdullatif; Al Thani, Asmaa A.; Marr, Nico; Yassine, Hadi M.... more authors ... less authors ( Universita Cattolica del Sacro Cuore , 2022 , Article)Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ... -
Development of an in-house COVID-19 serology ELISA Test
Chowdhury, Shazeda; Taleb, Sara; Elgamal, Mahmoud; Hassan, Nesyia; Nomikos, Michail; Hssain, Ali Ait; Zughaier, Susu M... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2021 , Article)Background: COVID-19 pandemic created an unprecedented demand for reagents and diagnostic tools to confirm COVID-19 cases. Thus, the development of a robust in-house diagnostic test is considered of high importance. Within ... -
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Kabeer, Basirudeen Syed Ahamed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; Liu, Li; Vempalli, Fazulur Rehaman; Mubarak, Ghada; Lorenz, Stephan; Sivieri, Irene; Cirmena, Gabriella; Dentone, Chiara; Cuccarolo, Paola; Giacobbe, Daniele Roberto; Baldi, Federico; Garbarino, Alberto; Cigolini, Benedetta; Cremonesi, Paolo; Bedognetti, Michele; Ballestrero, Alberto; Bassetti, Matteo; Hejblum, Boris P.; Augustine, Tracy; Van Panhuys, Nicholas; Thiebaut, Rodolphe; Branco, Ricardo; Chew, Tracey; Shojaei, Maryam; Short, Kirsty; Feng, Carl G.; Zughaier, Susu M.; De Maria, Andrea; Tang, Benjamin; Hssain, Ali Ait; Bedognetti, Davide; Grivel, Jean Charles; Chaussabel, Damien... more authors ... less authors ( American Association for the Advancement of Science , 2022 , Article)Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via ... -
In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein.
Mathew, Shilu; Taleb, Sara; Eid, Ali Hussein; Althani, Asmaa A; Yassine, Hadi M ( Springer , 2021 , Article)Human respiratory syncytial virus (RSV) is a leading ubiquitous respiratory pathogen in newborn infants, young children, and the elderly, with no vaccine available to date. The viral fusion glycoprotein (RSV F) plays an ... -
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
Hadi M., Yassine; Al-Jighefee, Hadeel; Al-Sadeq, Duaa W.; Dargham, Soha R.; Younes, Salma N.; Shurrab, Farah; Marei, Reham M.; Hssain, Ali Ait; Taleb, Sara; Alhussain, Hashim A.; Al-Nesf, Maryiam A.; Al-Khal, Abdullatif; Qotba, Hamda; Althani, Asmaa A.; Tang, Patrick; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2020 , Article)ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ... -
SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines
Zedan, Hadeel T.; Smatti, Maria K.; Al-Sadeq, Duaa W.; Al Khatib, Hebah A.; Nicolai, Eleonora; Pieri, Massimo; Bernardini, Sergio; Hssain, Ali Ait; Taleb, Sara; Qotba, Hamda; Issa, Khodr; Abu Raddad, Laith J.; Althani, Asmaa A.; Nasrallah, Gheyath K.; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody-dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we ...