Medicine Research: Recent submissions
Now showing items 461-480 of 1485
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Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Accumulation of advanced glycation endproducts (AGEs) is linked to decline in renal function, particularly in patients with diabetes. Major forms of AGEs in serum are protein-bound AGEs and AGE free adducts. In this study, ... -
An Introduction to the Special Issue “Protein Glycation in Food, Nutrition, Health and Disease”
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)On 20–24 September 2021, leading researchers in the field of glycation met online at the 14th International Symposium on the Maillard Reaction (IMARS-14), hosted by the authors of this introductory editorial, who are from ... -
Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic ... -
Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)This cross-sectional study examines knowledge, attitudes, and practices surrounding breast cancer awareness and screening among women residents in Qatar. Females, >18 years old, registered with the Primary Health Care ... -
AGEomics Biomarkers and Machine Learning—Realizing the Potential of Protein Glycation in Clinical Diagnostics
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Protein damage by glycation, oxidation and nitration is a continuous process in the physiological system caused by reactive metabolites associated with dicarbonyl stress, oxidative stress and nitrative stress, respectively. ... -
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. Increased MG glycation produces ... -
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ... -
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions ... -
Taxonomy of communications in the operating room
( Springer Verlag , 2018 , Conference Paper)US hospitals are facing critical problems of nurse shortage. One report predicts that there will be a shortage of 260,000 registered nurses by 2025 in the USA, and it was found out that patient mortality risk is 6% higher ... -
Prevalence and potential determinants of covid-19 vaccine hesitancy and resistance in qatar: Results from a nationally representative survey of qatari nationals and migrants between december 2020 and january 2021
( MDPI AG , 2021 , Article)Global COVID-19 pandemic containment necessitates understanding the risk of hesitance or resistance to vaccine uptake in different populations. The Middle East and North Africa currently lack vital representative vaccine ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ... -
Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
( Elsevier , 2023 , Article)BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ... -
A novel deep learning technique for morphology preserved fetal ECG extraction from mother ECG using 1D-CycleGAN
( Elsevier , 2024 , Article)The non-invasive fetal electrocardiogram (fECG) enables easy detection of developing heart abnormalities, leading to a significant reduction in infant mortality rate and post-natal complications. Due to the overlapping of ... -
Retraction to: Samaha et al. effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon. viruses 2021, 13, 989
( MDPI , 2021 , Other)The journal retracts the article, Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon [1], cited above. Following publication, ... -
Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration of Bruguiera gymnorhiza (L.) Lam.-A Traditionally Used Medicinal Halophyte
( MDPI , 2022 , Article)Decoctions (leaves and roots) of Bruguiera gymnorhiza (L.) Lam. are traditionally used against diabetes in many countries, including Mauritius. This study endeavoured to evaluate the inhibitory potential of leaves, roots, ... -
Reactive oxygen species: Modulators of phenotypic switch of vascular smooth muscle cells
( MDPI , 2020 , Article Review)Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated ... -
Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome
( MDPI , 2021 , Article Review)Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA ... -
Cardiac autonomic neuropathy: A progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders
( MDPI , 2020 , Article Review)Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular ... -
Therapeutic potential of resveratrol in covid-19-associated hemostatic disorders
( MDPI , 2021 , Article)Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19's outcome and severity. Dysfunctions of endothelial cells and platelets are tightly ... -
Effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon
( MDPI , 2021 , Article)Objective: This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 among asymptomatic subjects that tested positive ...
