Medicine Research: Recent submissions
Now showing items 541-560 of 1485
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The COVID-19 pandemic and healthcare systems in Africa: A scoping review of preparedness, impact and response
( BMJ Publishing Group , 2021 , Article)Background The COVID-19 pandemic has overwhelmed health systems in both developed and developing nations alike. Africa has one of the weakest health systems globally, but there is limited evidence on how the region is ... -
Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
( John Wiley and Sons Inc , 2021 , Article)Objective and design This study investigated the opposite mechanisms by which IL-1β and TGF-β1 modulated the inflammatory and migratory phenotypes in cultured human intimal vascular smooth muscle cells vSMCs. Materials ... -
Information on harm outcomes was insufficiently reported in systematic reviews and meta-analyses of individual participant data
( John Wiley and Sons Inc , 2021 , Other)Meta-analysis is an important tool for summarizing findings from scientific research. But for harm outcomes,issues may arise due to the distribution problems, zero-events problems, as well as low statistical power. Individual ... -
COVID-19 in Ethiopia: A geospatial analysis of vulnerability to infection, case severity and death
( BMJ Publishing Group , 2021 , Article)Background COVID-19 has caused a global public health crisis affecting most countries, including Ethiopia, in various ways. This study maps the vulnerability to infection, case severity and likelihood of death from COVID-19 ... -
Subcutaneous emphysema, pneumothorax, pneumomediastinum and pneumoperitoneum after upper gastrointestinal endoscopy
( NLM (Medline) , 2020 , Article)Upper gastrointestinal (GI) endoscopies are performed for several reasons. The overuse of endoscopy has negative effects on the quality of healthcare and pressurises endoscopy services. It also results in the complications. ... -
Worsening baroreflex sensitivity on progression to type 2 diabetes: Localized vs. systemic inflammation and role of antidiabetic therapy
( American Physiological Society , 2020 , Article)Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying ... -
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 complication severity
( American Society for Pharmacology and Experimental Therapy , 2021 , Article Review)ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage ... -
Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
( American Society for Pharmacology and Experimental Therapy (ASPET) , 2022 , Article)The evolving view of gut microbiota has shifted toward describing the colonic flora as a dynamic organ in continuous interaction with systemic physiologic processes. Alterations of the normal gut bacterial profile, known ... -
Could antigen presenting cells represent a protective element during sars-cov-2 infection in children?
( MDPI , 2021 , Article)Antigen Presenting Cells (APC) are immune cells that recognize, process, and present antigens to lymphocytes. APCs are among the earliest immune responders against an antigen. Thus, in patients with COVID-19, a disease ... -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
Construct validity of an instrument for assessment of reflective writing-based portfolios of medical students
( Dove Medical Press , 2020 , Article)Purpose: Assessment of reflective writing for medical students is challenging, and there is lack of an available instrument with good psychometric properties. The authors developed a new instrument for assessment of ... -
Cucurbituril Ameliorates Liver Damage Induced by Microcystis aeruginosa in a Mouse Model
( Frontiers , 2021 , Article)Microcystis aeruginosa is a cyanobacterium that produces a variety of cyclic heptapeptide toxins in freshwater. The protective effects of the macromolecular container cucurbit[7]uril (CB7) were evaluated using mouse models ... -
Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
( De Gruyter , 2021 , Article)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still ... -
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
( MDPI , 2022 , Article)The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that ... -
Evaluating the Effectiveness of Pretreatment With Intravenous Fluid in Reducing the Risk of Developing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis.
( cureus , 2022 , Article)Contrast media administration to patients during cardiac events increases the risk of developing contrast-induced nephropathy (CIN). CIN is among some complications usually associated with the percutaneous coronary ... -
A culturally competent approach to teaching humanities in an international medical school: potential frameworks and lessons learned.
( national library of medicine , 2022 , Article): This paper describes the development of a culturally competent medical humanities course for second and third-year medical students at the ethnically diverse College of Medicine at Qatar University. First taught in 2016, ... -
Hydroxychloroquine in COVID-19 Patients: Pros and Cons
( Frontiers Media S.A. , 2020 , Article)The pandemic of COVID-19, caused by SARS-CoV-2, has recently overwhelmed medical centers and paralyzed economies. The unparalleled public distress caused by this pandemic mandated an urgent quest for an effective approach ... -
Emotional and Clinical Challenges While Dealing With a Blind-Deaf-Mute Patient.
( Springer , 2020 , Article)A 43-year-old male, known to be deaf, mute, and blind, presented to the ED accompanied by his daughter. She said that he had multiple episodes of diarrhea and vomiting for two days. At first, it gave the impression of ... -
Juvenile Hyaline Fibromatosis: Literature Review and a Case Treated With Surgical Excision and Corticosteroid.
( Springer , 2020 , Article)Juvenile hyaline fibromatosis (JHF) is an extremely rare autosomal recessive disease with less than a hundred cases reported worldwide and is more prevalent in the middle east due to higher rates of interfamilial marriages. ... -
Virtual Reality Module Depicting Catheter-Associated Urinary Tract Infection as Educational Tool to Reduce Antibiotic Resistant Hospital-Acquired Bacterial Infections
( Institute of Electrical and Electronics Engineers Inc. , 2020 , Conference Paper)Virtual Reality (VR) and augmented reality (AR) are used as simulation models in student-patient interactive medical education and shown to enhance learning outcomes. The rise in global burden of infectious diseases ...
