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    Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia

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    VitD-Metabolomics (2.229Mb)
    Date
    2022-08-01
    Author
    Mousa, Hanaa
    Elrayess, Mohamed A.
    Diboun, Ilhame
    Jackson, Simon K.
    Zughaier, Susu M.
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    Abstract
    Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways.
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    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137381903&origin=inward
    DOI/handle
    http://dx.doi.org/10.3390/metabo12080771
    http://hdl.handle.net/10576/38317
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    • Biomedical Research Center Research [‎808‎ items ]
    • Medicine Research [‎1819‎ items ]

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