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AuthorAl Thani, Najlaa A.
AuthorHasan, Maram
AuthorYalcin, Huseyin C.
Available date2023-04-30T07:52:55Z
Publication Date2023-01-01
Publication NameJournal of Cardiovascular Translational Research
Identifierhttp://dx.doi.org/10.1007/s12265-023-10379-5
CitationAl Thani, N.A., Hasan, M. & Yalcin, H.C. Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors. J. of Cardiovasc. Trans. Res. (2023). https://doi.org/10.1007/s12265-023-10379-5
ISSN19375387
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152800999&origin=inward
URIhttp://hdl.handle.net/10576/42149
AbstractSodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. A good number of randomized clinical trials revealed that SGLT2is significantly prevented heart failure (HF) and cardiovascular death in T2DM patients. Despite ongoing clinical trials in HF patients without T2DM, there have been a limited number of translational studies on the cardioprotective properties of SGLT2is. As the cellular mechanism behind the cardiac benefits of SGLT2is is still to be elucidated, animal models are used to better understand the pathways behind the cardioprotective mechanism of SGLT2i. In this review, we summarize the animal models constructed to study the cardioprotective mechanisms of SGLT2is to help deliver a more comprehensive understanding of the in vivo work that has been done in this field and to help select the most optimal animal model to use when studying the different cardioprotective effects of SGLT2is. Graphical Abstract: [Figure not available: see fulltext.]
SponsorOpen Access funding provided by the Qatar National Library. Publication of the article is covered by Qatar National Library.
Languageen
PublisherSpringer
SubjectAnimal models
Canagliflozin
Cardioprotection
Diabetes
Empagliflozin
Gliflozins
Heart failure
SLGT2
TitleUse of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
TypeArticle Review
dc.accessType Open Access


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