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AuthorHoda, Najjar
AuthorAl-Ashmar, Sarah
AuthorQush, Abeer
AuthorAl-Asmar, Jawaher
AuthorRashwan, Sara
AuthorElgamal, Abdelrahman
AuthorZeidan, Asad
AuthorKamareddine, Layla
Available date2023-06-21T08:28:30Z
Publication Date2022-06-30
Publication NameMicrobes and Infection
Identifierhttp://dx.doi.org/10.1016/j.micinf.2022.104946
ISSN12864579
URIhttps://www.sciencedirect.com/science/article/pii/S1286457922000168
URIhttp://hdl.handle.net/10576/44646
AbstractOn quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's immune machinery are the paramount tools used by pathogens in their “arm race” against the host; here, we provide insight into another facet of pathogenic embitterment by presenting evidence of the ability of enteric pathogens to exhibit pathogenicity through modulating metabolic homeostasis in Drosophila melanogaster. We report that Escherichia coli and Shigella sonnei orally infected flies exhibit lipid droplet deprivation from the fat body, irregular accumulation of lipid droplets in the midgut, and significant elevation of systemic glucose and triglyceride levels. Our findings indicate that these detected metabolic alterations in infected flies could be attributed to differential regulation of peptide hormones known to be crucial for lipid metabolism and insulin signaling. Gaining a proper understanding of infection-induced alterations succours in curbing the pathogenesis of enteric diseases and sets the stage for promising therapeutic approaches to quarry infection-induced metabolic disorders.
SponsorThis work was supported by Qatar University internal grant (QUST-1-CHS-2019-10) awarded to Layla Kamareddine. Fly stocked used in this study were purchased from Bloomington Drosophila Stock Center. Microscopy was performed at the Microscopy Facility in the Research Complex (H10) at Qatar University.
Languageen
PublisherElsevier
SubjectEnteric pathogens
Metabolic alterations
Peptide hormones
Drosophila melanogaster
TitleEnteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host
TypeArticle
Issue Number4
Volume Number24
dc.accessType Open Access


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