Search

Now showing items 1-10 of 35

Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines

Sohail, Muhammad U.; Al-Mansoori, Layla; Al-Jaber, Hend; Georgakopoulos, Costas; Donati, Francesco; ... more authors ... less authors ( Frontiers Media , 2020 , Article)

© Copyright © 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botrè, Sellami and Elrayess. Objectives: Circulating cytokines and oxidative stress markers vary in response to different exercise regimens. This ...

Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes

Al-Mansoori, Layla; Al-Jaber, Hend; Madani, Aisha Y.; Mazloum, Nayef A.; Agouni, Abdelali; ... more authors ... less authors ( Elsevier , 2020 , Article)

© 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important ...

Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization

Nada, Khudair; Agouni, Abdelali; Elrayess, Mohamed A.; Najlah, Mohammad; Younes, Husam M.; ... more authors ... less authors ( Elsevier , 2020 , Article)

Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ...

Signal transducer and activator of transcription 3 (Stat3) suppresses stat1/interferon signaling pathway and inflammation in senescent preadipocytes

Madani, Aisha Y.; Majeed, Yasser; Abdesselem, Houari B.; Agha, Maha V.; Vakayil, Muneera; ... more authors ... less authors ( MDPI , 2021 , Article)

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT ...

Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women

Ramanjaneya, Manjunath; Diboun, Ilhame; Rizwana, Najeha; Dajani, Yaser; Ahmed, Lina; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

Introduction: Complement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the ...

Amniotic stem cells as a source of regenerative medicine to treat female infertility

Naeem, Aisha; Gupta, Nikita; Naeem, Usra; Elrayess, Mohamed A.; Albanese, Chris ( Springer , 2022 , Article Review)

Impaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. ...

In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity

Al-Jaber, Hend; Mohamed, Nura A.; Govindharajan, Vijay K.; Taha, Samir; John, Jomon; ... more authors ... less authors ( MDPI , 2022 , Article)

Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ...

Statistical methods and resources for biomarker discovery using metabolomics.

Anwardeen, Najeha R; Diboun, Ilhame; Mokrab, Younes; Althani, Asma A; Elrayess, Mohamed A ( BMC , 2023 , Article Review)

Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ...

The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection

Anwardeen, Najeha R.; Cyprian, Farhan S.; Yassine, Hadi M.; Al-Thani, Asmaa A.; Abdallah, Abdallah M.; ... more authors ... less authors ( Frontiers Media , 2023 , Article)

Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ...

Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells

Alheidous, Sara; Al-Muraikhy, Shamma; Rizk, Nasser; Sellami, Maha; Donati, Francesco; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

Introduction: The immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tissues and skeletal muscle cells, depending on sport intensity. In this study, the effect of serum from ...