Biomedical Research Center Research: Recent submissions
Now showing items 321-340 of 736
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Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity.
( Frontiers Media , 2022 , Article)Increased COVID-19 disease severity is higher among patients with type 2 diabetes mellitus and hypertension. However, the metabolic pathways underlying this association are not fully characterized. This study aims to ... -
Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.
( Springer , 2022 , Article)SARS-CoV-2 breakthrough infections in vaccinated individuals and in those who had a prior infection have been observed globally, but the transmission potential of these infections is unknown. The RT-qPCR cycle threshold ... -
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
( Elsevier , 2022 , Article)Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ... -
Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players
( Frontiers Media , 2021 , Article)Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim ... -
Whole genome sequencing of marine organisms by Oxford Nanopore Technologies: Assessment and optimization of HMW-DNA extraction protocols
( Wiley , 2021 , Article)Marine habitats are Earth's largest aquatic ecosystems, yet little is known about marine organism's genomes. Molecular studies can unravel their genetics print, thus shedding light on specie's adaptation and speciation ... -
One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar
( Frontiers , 2021 , Article)Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome ... -
Visible Light Photocatalytic Activity of Ag/WO3 Nanoparticles and its Antibacterial Activity Under Ambient Light and in The Dark
( Elsevier , 2022 , Article)Nanomaterial such as metals and metal oxide photocatalysts have emerged as important tools for removing contaminants from wastewater and as antibacterial agents to prevent infections; this is mainly due to their stability ... -
Comparison of antibody immune responses between BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in naïve and previously infected individuals.
( Oxford University Press , 2021 , Article)Two mRNA vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, obtained the Emergency Use Listing by WHO for preventing COVID-19. However, little is known about the difference in antibody responses induced by these two mRNA ... -
Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery
( Elsevier , 2021 , Article)The aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya ... -
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
( Elsevier , 2022 , Article)Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ... -
Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system
( Springer , 2021 , Article)Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of ... -
XPC multifaceted roles beyond DNA damage repair: p53-dependent and p53-independent functions of XPC in cell fate decisions
( Elsevier , 2022 , Article)Xeroderma pigmentosum group C protein (XPC) acts as a DNA damage recognition factor for bulky adducts and as an initiator of global genome nucleotide excision repair (GG-NER). Novel insights have shown that the role of XPC ... -
COVID-19 Vaccination: The Mainspring of Challenges and the Seed of Remonstrance
( MDPI , 2021 , Article Review)As of March 2020, the time when the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic, our existence has been threatened and the lives of ... -
Editorial: Unconventional Animal Models in Infectious Disease Research – Part I
( Frontiers Media , 2021 , Article)Editorial on the Research Topic Unconventional Animal Models in Infectious Disease Research -
Viral meningitis : an overview
( Springer-Verlag , 2021 , Article)Meningitis is a serious condition that affects the central nervous system. It is an inflammation of the meninges, which is the membrane that surrounds both the brain and the spinal cord. Meningitis can be caused by bacterial, ... -
Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
( Wiley , 2021 , Article)Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ... -
A preliminary study on microbial air contamination in select schools in Doha, Qatar
( Springer Nature , 2021 , Article)Available data of the indoor airborne culturable bacteria and fungi at schools’ environments is very limited in the peninsula of Qatar. This study aims to determine the microbial load in indoor and outdoor air at three ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( Hamad Bin Khalifa University Press , 2021 , Article)The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The spike ... -
In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein.
( Springer , 2021 , Article)Human respiratory syncytial virus (RSV) is a leading ubiquitous respiratory pathogen in newborn infants, young children, and the elderly, with no vaccine available to date. The viral fusion glycoprotein (RSV F) plays an ... -
Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality
( Frontiers Media , 2021 , Article)Globally, over two million people have perished due to the recent pandemic caused by SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher rate of severity and mortality in males. Analyzing ...