Biomedical Research Center Research: Recent submissions
Now showing items 381-400 of 740
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The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ... -
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors
( Qatar University Press , 2021 , Poster)Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI ... -
Investigation of potential rupture locations for abdominal aortic aneurysms with patient-specific computational fluid dynamic analysis approach
( Qatar University Press , 2021 , Poster)Background: About 18 million people die each year from cardiovascular disorders, accounting for 31% of all deaths worldwide. Abdominal Aortic Aneurysm (AAA) is a serious clinical condition manifested as dilation of the ... -
Direct Measurement of Vessel Pressure in Chicken Embryo during Development
( Qatar University Press , 2021 , Poster)Hemodynamic conditions play a critical role in embryonic cardiovascular development, and altered blood flow leads to congenital heart defects (CHD). Chicken embryos are commonly used as models of cardiac development, with ... -
Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening
( Qatar University Press , 2021 , Poster)Introduction: Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung condition. It is characterized by disruption of gas exchange inside the alveoli, accumulation of protein edema, and an increase in lung ... -
Experimental and Biological Investigation of Hemodynamics-induced Injuries for Cardiovascular Disorders
( Qatar University Press , 2021 , Poster)Introduction:Abdominal aortic aneurysm (AAA) is a degenerative disease process of the abdominal aorta that leads to a focal dilation and irreversible remodeling of the arterial wall. In this condition, the aortic vessel ... -
Genetic Susceptibility to Infectious Diseases in the Qatari Population
( Qatar University Press , 2021 , Poster)Background: Infectious diseases (IDs) account for 8% of deaths annually in Qatar, and therefore, represent a significant challenge for public health. Interestingly, the spread and severity of viral infections vary considerably ... -
Detection of antinuclear antibodies targeting intracellular signal transduction, metabolism, apoptotic processes and cell death in critical COVID-19 patients
( Qatar University Press , 2021 , Poster)Background: The heterogeneity of COVID-19 lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) has been shown to be the leading cause of mortality in COVID-19 ... -
Soluble ACE2 and Angiotensin II levels Modulated in Hypertensive COVID-19 Patients treated with different Antihypertension Drugs
( Qatar University Press , 2021 , Poster)Hypertension is a major risk factor and common comorbidity among severe Coronavirus Disease 2019 (COVID-19) patients. Prominent antihypertensive drugs, such as angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin ... -
Assessment of Human Fetal Left Heart Hemodynamics during Prenatal Development
( Qatar University Press , 2021 , Poster)The hemodynamic forces and wall shear stresses (WSS) play an important role during the fetal heart development. Abnormal levels of flow-driven shear stress can deteriorate the proper functioning of the cells responsible ... -
Patient Specific Transcatheter Aortic Valve Replacement Therapy Pathway with Computational Fluid Structure Interaction Analysis
( Qatar University Press , 2021 , Poster)Total cardiovascular disease (CVD) prevalence has risen dramatically from 271 million in 1990 to 523 million in 2019, and CVD fatalities rose gradually from 12.1 million in 1990 to 18.6 million in 2019. According to American ... -
Colorimetry-based Detection of Exhaled Breath Biomarkers for Predicting Heart Failure
( Qatar University Press , 2021 , Poster)The exhaled breath volatile organic compounds (VOC's) represent a biosignature with the potential to identify and describe heart failure diseases. Exhaled Breath biomarkers-based diagnosis of heart diseases may be easier ... -
Halloysite nanotubes and halloysite-based composites for biomedical applications
( Elsevier , 2021 , Article)Novel biomaterials for diagnostics and therapeutics of biomedical issues have been considered using biomedical science and health care. Halloysite nanotubes (HNTs) are naturally occurring aluminosilicate clay. Because of ... -
Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells
( Elsevier , 2021 , Article)Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue engineering strategies focusing on biomaterial scaffolds incorporating cells and growth factors are emerging as highly promising ... -
Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance
( Springer , 2021 , Article Review)Obesity, manifested by increased adiposity, represents a main cause of morbidity in the developed countries, causing increased risk of insulin resistance and type 2 diabetes mellitus. Recruitment of macrophages and activation ... -
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
( Frontiers Media , 2021 , Article)A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer ... -
Numerical Investigation of the Fetal Left Heart Hemodynamics During Gestational Stages
( Frontiers Media , 2021 , Article)Flow-driven hemodynamic forces on the cardiac tissues have critical importance, and have a significant role in the proper development of the heart. These mechanobiological mechanisms govern the cellular responses for the ... -
Is preexisting immunity to seasonal coronaviruses limited to cross-reactivity with SARS-CoV-2? A seroprevalence cross-sectional study in north-eastern France
( Elsevier , 2021 , Article)In light of the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there remain unanswered questions regarding the humoral immune response and ... -
Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime.
( Frontiers Media , 2021 , Article)Exercise training is one of the few therapeutic interventions that improves health span by delaying the onset of age-related diseases and preventing early death. The length of telomeres, the 5'-TTAGGG -3' tandem repeats ... -
Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients.
( Frontiers Media , 2021 , Article)Detection of early metabolic changes in critically-ill coronavirus disease 2019 (COVID-19) patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in ...
