عرض بسيط للتسجيلة

المؤلفZhang, H.
المؤلفLi, X.
المؤلفDeng, W.
المؤلفWang, X.
المؤلفWang, S.
المؤلفGe, J.
المؤلفToft, E.
تاريخ الإتاحة2023-09-18T09:52:25Z
تاريخ النشر2017
اسم المنشورFrontiers in Bioscience - Landmark
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.2741/4491
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47644
الملخصThe aim of this study was to investigate the drug release profiles of biodegradable polymer sirolimus- or paclitaxel-eluting stents with asymmetrical coating (BPSES-A or BPPES-A) both in vitro and in vivo. In vitro, the drug release profile was characterized by measuring the drug concentration by HPLC over a time-course. In vivo, a porcine aorta stenting model was employed. The results showed that the drug release rates of BPSES-A and BPPES-A were slower, more stable and less burst releasing than those of conventionally coated stents (BPSES-C and BPPES-C respectively), both in vitro and in vivo. Based on the in vivo results, the sirolimus and paclitaxel content of the local coronary wall was maintained at a higher and more effective level with BPSES-A and BPPES-A than with BPSES-C and BPPES-C, respectively. The drug levels in peripheral tissue samples were below detection levels. These data demonstrated the effectiveness of both sirolimus and paclitaxel as stent coating agents, and revealed the favorable drug release kinetics and pharmacokinetics of asymmetrical coated stents compared with conventional coated stents.
اللغةen
الناشرIMR Press Limited
الموضوعStents
Poly(Lactide)
Biodegradability
العنوانDrug release kinetics from a drug-eluting stent with asymmetrical coat
النوعArticle
الصفحات407-415
رقم العدد3
رقم المجلد22
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة